Evidence map›Paper›PMID 38492215›Full record

ArticleEuropean heart journal. Cardiovascular Imaging2024

Comparative prognostic importance of measures of left atrial structure and function in non-ischaemic dilated cardiomyopathy.

Daniel J Hammersley, Srinjay Mukhopadhyay, Xiuyu Chen, Leanne Cheng, Richard E Jones, Lukas Mach, Lara Curran, Momina Yazdani, Alma Iacob, Amrit S Lota and 11 more

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal. Cardiovascular Imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Clinical and prognostic impact of left atrial strain in non-ischemic cardiomyopathies.The international journal of cardiovascular imaging · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Observational
  7. Observational
  8. Left atrial volume as risk marker: is minimum volume superior to maximum volume?European heart journal. Cardiovascular Imaging · 2024
    Article
  9. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 3 countries.

Daniel J HammersleyNational Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK.ORCID 0000-0002-1164-5993
Srinjay MukhopadhyayNational Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK.
Xiuyu ChenState Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Fuwai Hospital, Beijing, China.
Leanne ChengNational Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK.
Richard E JonesNational Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK.
Lukas MachNational Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK.
Lara CurranNational Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK.
Momina YazdaniNational Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK.
Alma IacobNational Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK.
Amrit S LotaNational Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK.
Zohya KhaliqueNational Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK.
Antonio De MarvaoBritish Heart Foundation Centre of Research Excellence, School of Cardiovascular and Metabolic Medicine and Sciences, King's College London, London, UK.
Resham BaruahRoyal Brompton and Harefield Hospital, Guy's & St Thomas' NHS Foundation Trust, London, UK.
Kaushik GuhaPortsmouth Hospitals NHS Trust, Portsmouth, UK.
James S WareNational Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK.ORCID 0000-0002-6110-5880
John GregsonLondon School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0001-6084-166X
Shihua ZhaoState Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Fuwai Hospital, Beijing, China.
Dudley J PennellNational Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK.
Upasana TayalNational Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK.
Sanjay K PrasadNational Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK.
Brian P HallidayNational Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK.ORCID 0000-0002-5876-1748
Guy's and St Thomas' NHS Foundation Trust · GBChinese Academy of Medical Sciences & Peking Union Medical College · CNKing's College London · GBLondon School of Hygiene & Tropical Medicine · GBPortsmouth Hospitals NHS Trust · GB

Funding

Alexander Jansons Myocarditis UK FoundationBHF Intermediate Clinical Research Fellowship FS/ICRF/21/26019British Heart Foundation FS/CRTF/23/24444British Heart Foundation RE/18/4/34215British Heart Foundation Clinical Research Training Fellowship FS/CRTF/23/24444British Society for Heart Failure Research FellowshipMedical Research CouncilMRC Clinician Scientist Fellowship MR/W023830/1National Heart and Lung Institute FoundationNational Institute for Health ResearchNIHR Imperial College Biomedical Research CentreRosetrees TrustRoyal Brompton Cardiovascular Biomedical Research UnitRoyston Centre for Cardiomyopathy ResearchSir Jules Thorn Charitable Trust 21JTA
6 · The paper itself

Abstract

aimsThis study aimed to compare the association between measures of left atrial (LA) structure and function, derived from cardiovascular magnetic resonance (CMR), with cardiovascular death or non-fatal heart failure events in patients with non-ischaemic dilated cardiomyopathy (DCM). METHODS AND

resultsCMR studies of 580 prospectively recruited patients with DCM in sinus rhythm [median age 54 (interquartile range 44-64) years, 61% men, median left ventricular ejection fraction 42% (30-51%)] were analysed for measures of LA structure [LA maximum volume index (LAVImax) and LA minimum volume index (LAVImin)] and function (LA emptying fraction, LA reservoir strain, LA conduit strain (LACS), and LA booster strain]. Over a median follow-up of 7.4 years, 103 patients (18%) met the primary endpoint. Apart from LACS, each measure of LA structure and function was associated with the primary endpoint after adjusting for other important prognostic variables. The addition of each LA metric to a baseline model containing the same important prognostic covariates improved model discrimination, with LAVImin providing the greatest improvement [C-statistic improvement: 0.702-0.738; χ2 test comparing likelihood ratio P < 0.0001; categorical net reclassification index: 0.210 (95% CI 0.023-0.392)]. Patients in the highest tercile of LAVImin had similar event rates to those with persistent atrial fibrillation. Measures of LA strain did not enhance model discrimination above LA volumetric measures.

conclusionMeasures of LA structure and function offer important prognostic information in patients with DCM and enhance the prediction of adverse outcomes. LA strain was not incremental to volumetric analysis for risk prediction.

Indexed as

Atrial Function, LeftCardiomyopathy, DilatedMagnetic Resonance Imaging, CineAdultCohort StudiesFemaleHeart AtriaHumansMaleMiddle AgedPrognosisProspective StudiesRisk AssessmentStroke Volumedilated cardiomyopathyleft atriumrisk predictionstrain

Identifiers

PMID38492215
PMCPMC11522868
OpenAlexW4392895995

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.