The first case of six-way complex translocation of t(4;7;9;22;8;14) in a patient with chronic myeloid leukemia.

Xiaoyu Bi, Chao Li, Miao Shang, Bingbing Han, Hongyu Li, Lidan Sun, Yani Lin, Shaobin Yang

Abstract readCase Reports

In one paragraph

Article in Journal of hematopathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaoyu Bi *Department of Cytogenetics, Sino-US Diagnostics Lab, Tianjin Enterprise Key Laboratory of Al-Aided Hematopathology Diagnosis, 5 Xinghua No.3 Branch Road, Tianjin, China.

Chao Li *Department of Hematology, Nanyang Central Hospital, Nanyang, Henan, China.

Miao ShangDepartment of Hematology, Nanyang Central Hospital, Nanyang, Henan, China.

Bingbing HanDepartment of Cytogenetics, Sino-US Diagnostics Lab, Tianjin Enterprise Key Laboratory of Al-Aided Hematopathology Diagnosis, 5 Xinghua No.3 Branch Road, Tianjin, China.

Hongyu LiDepartment of Cytogenetics, Sino-US Diagnostics Lab, Tianjin Enterprise Key Laboratory of Al-Aided Hematopathology Diagnosis, 5 Xinghua No.3 Branch Road, Tianjin, China.

Lidan SunDepartment of Cytogenetics, Sino-US Diagnostics Lab, Tianjin Enterprise Key Laboratory of Al-Aided Hematopathology Diagnosis, 5 Xinghua No.3 Branch Road, Tianjin, China.

Yani LinDepartment of Cytogenetics, Sino-US Diagnostics Lab, Tianjin Enterprise Key Laboratory of Al-Aided Hematopathology Diagnosis, 5 Xinghua No.3 Branch Road, Tianjin, China. hbyangshaobin@163.com.

Shaobin YangDepartment of Cytogenetics, Sino-US Diagnostics Lab, Tianjin Enterprise Key Laboratory of Al-Aided Hematopathology Diagnosis, 5 Xinghua No.3 Branch Road, Tianjin, China. yanilin@sino-us-diagnostics.com.ORCID http://orcid.org/0000-0003-3057-3603

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In chronic myeloid leukemia (CML), patients exhibit the t(9;22)(q34.1;q11.2) translocation, resulting in the formation of a Philadelphia chromosome (Ph). However, a subset of CML patients display variant complex translocations, characterized by three-way, four-way, and five-way translocations, which have been occasionally associated with a poor prognosis. This case report presents the first case of a t(9;22) variant six-way complex translocation in CML. The R banding chromosome karyotyping technique was used to obtain preliminary karyotyping results, and the multi-probe FISH technique was used to assist in the verification of chromosome results. Both FISH and PCR proved the existence of fusion genes. A 45-year-old male patient admitted to our hospital due to elevated WBC and anemia. Bone marrow smears revealed a significant proliferation of mature granulocytes, accompanied by an increase in eosinophils and basophils. Karyotype analysis indicated abnormalities in six chromosomes, including 4, 7, 8, 9, 14, and 22. Further analysis using FISH technology demonstrated the presence of the BCR::ABL1 fusion gene, as well as the mapping of the BCR (22q11), MYC (8q24), IGH (14q32), D4S163 (4q35.1), and D7S486 (7q31) genes to new chromosomes. Ultimately, the karyotype findings were described as t(4;7;9;22;8;14)(q27;q22;q34;q11;q22;q12). PCR showed that BCR::ABL1 was p210. After treatment with imatinib for 4 months, the patient achieved complete cytogenetic response (CCyR) and early molecular response (EMR). This is the first report of complex chromosomal karyotype involving six-way translocation in CML; the combination of chromosome analysis and FISH techniques is an effective strategy in determining the karyotype result.

Indexed as

Leukemia, Myelogenous, Chronic, BCR-ABL PositiveTranslocation, GeneticChromosomes, Human, Pair 22Fusion Proteins, bcr-ablHumansImatinib MesylateIn Situ Hybridization, FluorescenceKaryotypingMaleMiddle AgedFusion Proteins, bcr-ablImatinib MesylateBCR::ABL1CMLSix-way translocationVariant Ph translocation

Identifiers

PMID38492169

DOI10.1007/s12308-024-00577-8

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.