Evidence map›Paper›PMID 38492107›Full record

ArticleBulletin of experimental biology and medicine2024

Structural Changes in Rat Hepatocyte Nucleolus under Nucleolar Stress Caused by Hypothermia.

I P Bobrov, A Yu Dolgatov, A V Lepilov, N A Korsikov, E S Dolgatova, M G Klinnikova, E L Lushnikova

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Article in Bulletin of experimental biology and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

I P BobrovAltai State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia.
A Yu DolgatovAltai State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia.
A V LepilovAltai State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia.
N A KorsikovAltai State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia.
E S DolgatovaAltai State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia.
M G KlinnikovaInstitute of Molecular Pathology and Pathomorphology, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia.
E L LushnikovaInstitute of Molecular Pathology and Pathomorphology, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia. pathol@inbox.ru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Structural changes in rat hepatocyte nucleoli were studied during deep hypothermia simulated by immersion in water at 5°C for 40 min (ambient air temperature 7°C). In comparison with the control, phenomena of nucleolar stress occurred in rats during hypothermia: the number of fibrillar centers (FC) per nucleus (by 1.7 times) and per nucleolus (by 1.6 times), nucleolonemal nucleoli per nucleus (by 2.8 times), and the relative content of nucleolonemal nucleoli per nucleus (by 2.6 times) significantly decreased (p=0.0000001); the number of FC per nucleolonemal nucleolus also decreased by 1.4 times (p=0.01). In the hepatocyte nuclei, we observed an increase in the relative content of transitional type nucleoli per nucleus (by 1.3 times; p=0.01), the number of FC per transitional type nucleolus (by 1.4 times; p=0.003), the content of free FC per nucleus (by 3 times; p=0.00004), and the percentage of free FC per nucleus (by 3.5 times; p=0.00004). These changes can be considered as compensatory and adaptive reactions, and transitional type nucleoli can be attributed to the "reserve" nucleolar pool.

Indexed as

HypothermiaAnimalsCell NucleolusHepatocytesNucleolus Organizer RegionRatshepatocyteshypothermianucleolar organizersnucleolar stressstrokes-imprints

Identifiers

PMID38492107

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