Evidence map›Paper›PMID 38492105›Full record

ArticleBulletin of experimental biology and medicine2024

Expression of TLR2, IL-1β, and IL-10 Genes as a Possible Factor of Successful or Pathological Aging in Nonagenarians.

S O Lukyanova, O V Artemyeva, I D Strazhesko, E D Nasaeva, V V Grechenko, L V Gankovskaya

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
4.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Changes in Innate Immunity and Microbiome in Different Aging Phenotypes.Bulletin of experimental biology and medicine · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

S O LukyanovaPirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
O V ArtemyevaPirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia. artemyevaov@yandex.ru.
I D StrazheskoPirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
E D NasaevaPirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
V V GrechenkoPirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
L V GankovskayaPirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
Ministry of Health of the Russian Federation · RUPirogov Russian National Research Medical University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The expression of the gene of pattern recognition receptor TLR2, proinflammatory cytokine IL-1β, and anti-inflammatory cytokine IL-10 was analyzed in the peripheral blood of nonagenarians (n=219; mean age 92.1 years, 77 men and 142 women) in comparison with healthy young donors (n=24; mean age 22.5 years, 16 women and 8 men). Nonagenarians were interviewed, medical records were analyzed, and a comprehensive geriatric assessment was performed according to the Clinical Guidelines on Frailty. The level of gene expression was determined by real-time PCR. The participation of inflammatory mechanisms in the immunosenescence was revealed. It was shown that increased expression of IL1B and TLR2 genes is associated with the development of frailty in nonagenarians and can be a factor of pathological aging. Increased expression of IL10 gene can be considered as a factor of successful aging in nonagenarians.

Indexed as

FrailtyInterleukin-10Interleukin-1betaToll-Like Receptor 2AdultAgedAged, 80 and overAgingCytokinesFemaleHumansMaleNonagenariansYoung AdultCytokinesIL10 protein, humanIL1B protein, humanInterleukin-10Interleukin-1betaTLR2 protein, humanToll-Like Receptor 2cytokinesgene expressioninflammaginglongevityTLR

Identifiers

PMID38492105
OpenAlexW4392882232

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.