Evidence map›Paper›PMID 38492101›Full record

ArticleBulletin of experimental biology and medicine2024

Immunohistochemical Analysis of Mitochondrial Dynamics in Different Zones of the Hippocampus during Experimental Modeling of Alzheimer's Disease.

T I Baranich, K A Skvortsova, D N Voronkov, A V Egorova, A S Averchuk, M V Ryazanova, A V Stavrovskaya, V V Glinkina, A B Salmina, V S Sukhorukov

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Mitochondrial Dynamics in Brain Cells During Normal and Pathological Aging.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

T I BaranichResearch Center of Neurology, Moscow, Russia. baranich_tatyana@mail.ru.
K A SkvortsovaResearch Center of Neurology, Moscow, Russia.
D N VoronkovResearch Center of Neurology, Moscow, Russia.
A V EgorovaResearch Center of Neurology, Moscow, Russia.
A S AverchukResearch Center of Neurology, Moscow, Russia.
M V RyazanovaResearch Center of Neurology, Moscow, Russia.
A V StavrovskayaResearch Center of Neurology, Moscow, Russia.
V V GlinkinaPirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
A B SalminaResearch Center of Neurology, Moscow, Russia.
V S SukhorukovResearch Center of Neurology, Moscow, Russia.
Research Center of Neurology · RUMinistry of Health of the Russian Federation · RUPirogov Russian National Research Medical University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We performed a comparative assessment of the immunohistochemical distribution of markers of mitochondrial fission (Drp-1), mitochondrial fusion (Mfn-2), and mitochondrial biogenesis (PGC-1α) in pyramidal neurons of different zones of the hippocampus in mice with intrahippocampal administration of β-amyloid peptide 25-35. The most pronounced changes in the dynamics associated with a decrease in the amount of the fission marker and an increase in the amount of the fusion marker were observed in the CA3 field on day 38 after peptide administration. In the CA1 field, a significant decrease in the marker of mitochondrial biogenesis PGC-1α was found on day 38, which can indicate a decrease in the intensity of mitochondrial biogenesis. Early mitochondrial changes can play an important role in the pathogenesis of all types of memory impairment in Alzheimer's disease.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsHippocampusMiceMitochondriaMitochondrial DynamicsAmyloid beta-PeptidesAlzheimer’s diseasehippocampusmitochondrianeurons

Identifiers

PMID38492101
OpenAlexW4392885231

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.