Evidence map›Paper›PMID 38492099›Full record

ArticleBulletin of experimental biology and medicine2024

Polymorphism in Genes Encoding Adaptor Proteins ST13 and STIP1 and the Risk of Ischemic Stroke: a Pilot Study.

T A Stetskaya, A B Krapiva, K A Kobzeva, D E Gurtovoy, G V Komkova, A V Polonikov, O Yu Bushueva

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Article in Bulletin of experimental biology and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

T A StetskayaLaboratory of Statistical Genetics and Bioinformatics, Research Institute of Genetics and Molecular Epidemiology, Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
A B KrapivaLaboratory of Genomic Research, Research Institute of Genetic and Molecular Epidemiology, Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
K A KobzevaLaboratory of Genomic Research, Research Institute of Genetic and Molecular Epidemiology, Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
D E GurtovoyLaboratory of Genomic Research, Research Institute of Genetic and Molecular Epidemiology, Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
G V KomkovaDepartment of Biology, Medical Genetics, and Ecology, Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
A V PolonikovLaboratory of Statistical Genetics and Bioinformatics, Research Institute of Genetics and Molecular Epidemiology, Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
O Yu BushuevaLaboratory of Genomic Research, Research Institute of Genetic and Molecular Epidemiology, Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia. olga.bushueva@inbox.ru.
Ministry of Health of the Russian Federation · RUKursk State Medical University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adaptor proteins stress induced phosphoprotein 1 (STIP1) and ST13 Hsp70 interacting protein (ST13) may play a crucial role in the pathophysiology of ischemic stroke through controlling protein folding, neuronal survival, and regulation of HSP70/HSP90. The present pilot study investigated whether tagSNPs in genes encoding ST13 (rs138335, rs138344, rs7290793, and rs138344) and STIP1 (rs4980524) are associated with ischemic stroke. DNA samples from 721 ischemic stroke patients and 471 healthy controls were genotyped using the MassArray-4. Our research revealed a relationship between rs138344 ST13 and the risk of ischemic stroke, which was seen only in females (risk allele G; OR=1.34, 95%CI=1.07-1.69; p=0.01). The haplotype rs138335G-rs138344C-rs7290793C ST13 was linked with lower risk of ischemic stroke in females: OR=0.42; 95%CI=0.26-0.68; p=0.0005. Thus, ST13 represents a novel genetic marker for ischemic stroke.

Indexed as

Heat-Shock ProteinsIschemic StrokeMolecular ChaperonesTumor Suppressor ProteinsFemaleGenotypeHSP70 Heat-Shock ProteinsHumansPilot ProjectsPolymorphism, GeneticHeat-Shock ProteinsHSP70 Heat-Shock ProteinsMolecular ChaperonesST13 protein, humanSTIP1 protein, humanTumor Suppressor Proteinsheat shock proteinsischemic strokers138344ST13STIP1

Identifiers

PMID38492099
OpenAlexW4392884906

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.