Evidence map›Paper›PMID 38492083›Full record

ArticleArchives of gynecology and obstetrics2024

The contradictive findings between ultrasound, hysteroscopy and cytokines in women with nonhormonal IUDs suffering from menorrhagia: a prospective study.

Hadel Watad, Udi Ifrach, David Stockheim, Vered Yulzari, Orly C Meron, Miri Blank, Benjamin Sredni, Boaz Weisz, Shlomo B Cohen

Open access · hybridAbstract read
In one paragraph

Article in Archives of gynecology and obstetrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Hadel WatadDepartment of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel-Hashomer, Israel. Hadeel.wattad@mail.huji.ac.il.ORCID http://orcid.org/0000-0001-9011-0294
Udi IfrachBar-Ilan University, Ramat Gan, Israel.
David StockheimDepartment of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Vered YulzariDepartment of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Orly C MeronThe Interdisciplinary Department of Social Sciences, Bar-Ilan University, Ramat Gan, Israel.
Miri BlankZabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Affiliated to the Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Benjamin SredniC.A.I.R. Institute, The Safdié AIDS and Immunology Research Center, The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.
Boaz WeiszDepartment of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Shlomo B CohenDepartment of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Tel Aviv University · ILBar-Ilan University · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe objective of this study is to assess the correlation between bleeding irregularities and the accurate placement of the intrauterine device (IUD) device in the uterine cavity, determined through transvaginal ultrasonography and hysteroscopy. In addition, the study aims to examine the cytokine profile in the uterine cavity and serum of patients experiencing bleeding irregularities after the insertion of nonhormonal IUDs.

methodsA prospective cohort study was conducted at a single tertiary medical center, wherein patients experiencing intermenstrual bleeding and spotting after the insertion of nonhormonal IUDs were enrolled. The study involved hysteroscopic and sonographic assessments of the uterine cavity and IUD placement, along with the analysis of blood and uterine cavity cytokine profiles.

resultsDuring the period between July 2019 and February 2020, a total of eight patients who experienced intermenstrual bleeding and spotting after the insertion of nonhormonal IUDs were enrolled the study. One case was excluded since a progestative device was detected by ultrasound. Out of the five cases that underwent a thorough ultrasonographic assessment, three cases (60%) showed an embedded IUD. However, these findings were excluded by the hysteroscopic evaluation.

conclusionThe results suggest that ultrasonographic assessment may lead to an overdiagnosis of IUD mispositioning compared to hysteroscopy. In addition, both ultrasound and hysteroscopy have limitations in diagnosing the cause of bleeding in most cases. The role of local reactive inflammatory cytokines should be further studied.

Indexed as

Intrauterine DevicesMenorrhagiaMetrorrhagiaCytokinesFemaleHemorrhageHumansHysteroscopyPregnancyProspective StudiesUltrasonographyCytokinesContraceptionEmbeddingInflammatoryIntermenstrual bleeding

Identifiers

PMID38492083
PMCPMC11018669
OpenAlexW4392880559

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.