ArticleEuropean archives of psychiatry and clinical neuroscience2024
Proinflammatory cytokine levels, cognitive function, and suicidal symptoms of adolescents and young adults with major depressive disorder.
Article in European archives of psychiatry and clinical neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Association of Cognitive Function With Event-Related Potentials and Immune Inflammation in Adolescents With Major Depressive Disorder.Brain and behavior · 2026Article
- Investigating NF-κB as a biomarker for suicidal ideation in depression in a pilot case-control study.Discover mental health · 2026Article
- Inflammation and treatment strategies for suicidal behavior.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2026Review
- Inflammation and suicide risk in adolescents with self-injury: Expanding the role of mental health nursing.World journal of psychiatry · 2026Article
- Can vegetables intake pattern mediate the relationship between fast-food and cognitive performance in adolescents? The Cogni-Action project.European journal of nutrition · 2026Article
- Pro-inflammatory cytokines level in depressed patients with suicidal behaviour: a systematic review and meta-analysis.Annals of general psychiatry · 2025Article
- Epigenetics and immunology: Under-recognized aspects of suicidality.World journal of psychiatry · 2025Review
- Inflammatory markers and suicidal behavior: A comprehensive review of emerging evidence.Annals of general psychiatry · 2025Review
- Pentoxifylline Prevents Neuroinflammation and Modifies PTEN/TrkB Signaling in an LPS-Induced Depression Model.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025Article
- Comprehensive view of suicide: A neuro-immune-endocrine approach.World journal of psychiatry · 2025Review
- Association between interleukin-27 and suicidal ideation: a Mendelian randomization analysis and peripheral blood experimental study.Frontiers in psychiatry · 2025Article
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Authors and funding
5 authors.
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Abstract
Whether proinflammatory cytokine dysregulation and cognitive dysfunction are associated with suicidal symptoms in adolescents and young adults with major depressive disorder (MDD) remains uncertain. We assessed the cognitive function and proinflammatory cytokine levels of 43 and 51 patients aged 15-29 years with MDD and severe and mild suicidal symptoms, respectively, as well as those of 85 age- and sex-matched healthy controls. Specifically, we measured serum levels of C-reactive protein, tumor necrosis factor-α (TNF-α), interleukin-2, and interleukin-6 and assessed cognitive function by using working memory and go/no-go tasks. The severity of the patients' suicidal symptoms was based on Item 10 of the Montgomery-Åsberg Depression Rating Scale; scores of ≤ 2 and ≥ 4 indicated mild and severe symptoms, respectively. The patients with MDD and severe suicidal symptoms had higher levels of C-reactive protein (p = .019) and TNF-α (p = .002) than did the patients with mild symptoms or the healthy controls. The number of errors committed on the go/no-go by patients with MDD and severe suicidal symptoms (p = .001) was significantly higher than those by patients with MDD and mild symptoms or by controls. After adjusting for nonsuicidal depressive symptoms, we observed suicidal symptoms to be positively associated with TNF-α levels (p = .050) and errors on the go/no-go task (p = .021). Compared with mild suicidal symptoms, severe symptoms are associated with greater serum levels of proinflammatory cytokines and inferior cognitive function in adolescents and young adults with MDD.
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