Evidence map›Paper›PMID 38492004›Full record

ArticleEuropean radiology2024

Enhancing gadoxetic acid-enhanced liver MRI: a synergistic approach with deep learning CAIPIRINHA-VIBE and optimized fat suppression techniques.

Hong Wei, Jeong Hee Yoon, Sun Kyung Jeon, Jae Won Choi, Jihyuk Lee, Jae Hyun Kim, Marcel Dominik Nickel, Bin Song, Ting Duan, Jeong Min Lee

Open access · hybridAbstract read
In one paragraph

Article in European radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

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  14. Deep learning-based reconstruction and superresolution for MR-guided thermal ablation of malignant liver lesions.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025
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  18. Deep Learning-accelerated MRI in Body and Chest.Journal of computer assisted tomography
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 5 countries.

Hong WeiDepartment of Radiology, Seoul National University Hospital, Seoul, 03080, Republic of Korea.
Jeong Hee YoonDepartment of Radiology, Seoul National University Hospital, Seoul, 03080, Republic of Korea.
Sun Kyung JeonDepartment of Radiology, Seoul National University Hospital, Seoul, 03080, Republic of Korea.
Jae Won ChoiDepartment of Radiology, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.
Jihyuk LeeDepartment of Radiology, Seoul National University Hospital, Seoul, 03080, Republic of Korea.
Jae Hyun KimDepartment of Radiology, Seoul National University Hospital, Seoul, 03080, Republic of Korea.
Marcel Dominik NickelMR Application Predevelopment, Siemens Healthcare GmbH, Henkestr. 127, 91052, Erlangen, Germany.
Bin SongDepartment of Radiology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Ting DuanDepartment of Radiology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Jeong Min LeeDepartment of Radiology, Seoul National University Hospital, Seoul, 03080, Republic of Korea. jmsh@snu.ac.kr.ORCID http://orcid.org/0000-0003-0561-8777
Seoul National University · KRSichuan University · CNSeoul National University Hospital · KRNew Generation University College · ETSiemens Healthineers (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate whether a deep learning (DL) controlled aliasing in parallel imaging results in higher acceleration (CAIPIRINHA)-volumetric interpolated breath-hold examination (VIBE) technique can improve image quality, lesion conspicuity, and lesion detection compared to a standard CAIPIRINHA-VIBE technique in gadoxetic acid-enhanced liver MRI.

methodsThis retrospective single-center study included 168 patients who underwent gadoxetic acid-enhanced liver MRI at 3 T using both standard CAIPIRINHA-VIBE and DL CAIPIRINHA-VIBE techniques on pre-contrast and hepatobiliary phase (HBP) images. Additionally, high-resolution (HR) DL CAIPIRINHA-VIBE was obtained with 1-mm slice thickness on the HBP. Three abdominal radiologists independently assessed the image quality and lesion conspicuity of pre-contrast and HBP images. Statistical analyses involved the Wilcoxon signed-rank test for image quality assessment and the generalized estimation equation for lesion conspicuity and detection evaluation.

resultsDL and HR-DL CAIPIRINHA-VIBE demonstrated significantly improved overall image quality and reduced artifacts on pre-contrast and HBP images compared to standard CAIPIRINHA-VIBE (p < 0.001), with a shorter acquisition time (DL vs standard, 11 s vs 17 s). However, the former presented a more synthetic appearance (both p < 0.05). HR-DL CAIPIRINHA-VIBE showed superior lesion conspicuity to standard and DL CAIPIRINHA-VIBE on HBP images (p < 0.001). Moreover, HR-DL CAIPIRINHA-VIBE exhibited a significantly higher detection rate of small (< 2 cm) solid focal liver lesions (FLLs) on HBP images compared to standard CAIPIRINHA-VIBE (92.5% vs 87.4%; odds ratio = 1.83; p = 0.036).

conclusionDL and HR-DL CAIPIRINHA-VIBE achieved superior image quality compared to standard CAIPIRINHA-VIBE. Additionally, HR-DL CAIPIRINHA-VIBE improved the lesion conspicuity and detection of small solid FLLs. DL and HR-DL CAIPIRINHA-VIBE hold the potential clinical utility for gadoxetic acid-enhanced liver MRI. CLINICAL RELEVANCE STATEMENT: DL and HR-DL CAIPIRINHA-VIBE hold promise as potential alternatives to standard CAIPIRINHA-VIBE in routine clinical liver MRI, improving the image quality and lesion conspicuity, enhancing the detection of small (< 2 cm) solid focal liver lesions, and reducing the acquisition time. KEY POINTS: • DL and HR-DL CAIPIRINHA-VIBE demonstrated improved overall image quality and reduced artifacts on pre-contrast and HBP images compared to standard CAIPIRINHA-VIBE, in addition to a shorter acquisition time. • DL and HR-DL CAIPIRINHA-VIBE yielded a more synthetic appearance than standard CAIPIRINHA-VIBE. • HR-DL CAIPIRINHA-VIBE showed improved lesion conspicuity than standard CAIPIRINHA-VIBE on HBP images, with a higher detection of small (< 2 cm) solid focal liver lesions.

Indexed as

Contrast MediaDeep LearningGadolinium DTPAImage EnhancementLiver NeoplasmsMagnetic Resonance ImagingAdultAgedAged, 80 and overArtifactsBreath HoldingFemaleHumansImage Interpretation, Computer-AssistedLiverMaleContrast MediaGadolinium DTPAgadolinium ethoxybenzyl DTPACAIPIRINHADeep learningLiverMagnetic resonance imagingVIBE

Identifiers

PMID38492004
PMCPMC11399219
OpenAlexW4392880766

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.