ArticleJournal of clinical hypertension (Greenwich, Conn.)2024
Joint association and interaction of birth weight and lifestyle with hypertension: A cohort study in UK Biobank.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- Chronic pain and incident hypertension: an observational study of 0.4 million adults.Journal of health, population, and nutrition · 2025Observational
- Joint association and interaction of birth weight and lifestyle with hypertension: A cohort study in UK Biobank.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- Influence of Integrated Chronic Disease Management Measures in Rural Medical Alliance on Health-Related Quality of Life of Hypertension Outpatients.Inquiry : a journal of medical care organization, provision and financingArticle
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Low birth weight and unhealthy lifestyle are both associated with an increased risk of hypertension. The authors aimed to assess the joint association and interaction of birth weight and lifestyle with incident hypertension. The authors included 205 522 participants free of hypertension at baseline from UK Biobank. A healthy lifestyle score was constructed using information on body mass index, physical activity, diet, smoking status and alcohol intake. Cox proportional hazard models were used to investigate the impact of birth weight, healthy lifestyle score and their joint effect on hypertension. The authors documented 13 548 (6.59%) incident hypertension cases during a median of 8.6 years of follow-up. The multivariate adjusted hazard ratios and 95% confidence intervals were 1.12 (1.09, 1.15) per kg lower birth weight and 0.76 (0.75, 0.77) per score increment in healthy lifestyle score. Healthy lifestyle reduced the risk of hypertension in any category of different birth weight groups. The preventive effect of healthy lifestyle on hypertension was the most pronounced at lower birth weight with <2500 g and 2500-2999 g, respectively. Addictive interaction between birth weight and healthy lifestyle score was observed with the relative excess risk due to interaction of 0.04 (0.03, 0.05). Our findings emphasized the importance of healthy lifestyle for hypertension prevention, especially among the high-risk population with lower birth weight.
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