Evidence map›Paper›PMID 38491746›Full record

ArticleJournal of neurochemistry2024

Excitotoxic glutamate levels cause the secretion of resident endoplasmic reticulum proteins.

Amanda M Dossat, Kathleen A Trychta, Elliot J Glotfelty, Joshua J Hinkle, Lowella V Fortuno, Lana N Gore, Christopher T Richie, Brandon K Harvey

Open access · hybridAbstract read
In one paragraph

Article in Journal of neurochemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Amanda M DossatIntramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland, USA.
Kathleen A TrychtaIntramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland, USA.
Elliot J GlotfeltyIntramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland, USA.ORCID 0000-0001-5125-8720
Joshua J HinkleIntramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland, USA.
Lowella V FortunoIntramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland, USA.
Lana N GoreIntramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland, USA.
Christopher T RichieIntramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland, USA.
Brandon K HarveyIntramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland, USA.ORCID 0000-0002-4036-1383
National Institute on Drug Abuse · US

Funding

Cellular mechanisms of neuronal dysfunction in addiction and neurodegenerationZIADA000618 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI HARVEY, BRANDON · 2017 to 2025
$12.9M
Intramural NIH HHS ZIA DA000618NIDA NIH HHS
6 · The paper itself

Abstract

Dysregulation of synaptic glutamate levels can lead to excitotoxicity such as that observed in stroke, traumatic brain injury, and epilepsy. The role of increased intracellular calcium (Ca

Indexed as

Endoplasmic ReticulumGlutamic AcidNeuronsAnimalsCalciumCells, CulturedCerebral CortexMiceRatsReceptors, GlutamateCalciumGlutamic AcidReceptors, Glutamateendoplasmic reticulumER calciumexcitotoxicityglutamateKDEL receptorproteostasis

Identifiers

PMID38491746
PMCPMC11401966
OpenAlexW4392882715

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.