ArticleEuropean journal of medical research2024
A non-linear connection between the total cholesterol to high-density lipoprotein cholesterol ratio and stroke risk: a retrospective cohort study from the China Health and Retirement Longitudinal Study.
Article in European journal of medical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Association Between Cholesterol-HDL-Glucose Index and Stroke Risk in Middle-Aged and Elderly Adults Without Diabetes: Evidence From Two National Cohort Studies.Cardiology research · 2026Article
- Total Cholesterol, High-Density Lipoprotein, and Glucose (CHG) index and risk of stroke in middle-aged and elderly Chinese adults: a nationwide prospective cohort study.BMC neurology · 2026Article
- Associations between the CHG index, its modified versions and incident stroke in patients with early-stage CKM syndrome: a nationwide cohort study.European journal of medical research · 2026Article
- Association between the triglyceride glucose-waist-to-height ratio and stroke risk among middle-aged and elderly Chinese adults.BMC endocrine disorders · 2025Article
- Evaluating the role of CHG index in predicting stroke risk among adults with varying glucose regulation.Aging clinical and experimental research · 2025Article
- Non-linear relationship between the triglyceride glucose-a body shape index and stroke risk: a prospective cohort study from the China health and retirement longitudinal study.Diabetology & metabolic syndrome · 2025Article
- The association between dolutegravir based first-line antiretroviral regimens and dyslipidemia among adults living with HIV on follow-up at health facilities in Hawassa city administration, Sidama region: a cross-sectional study.Atherosclerosis plus · 2025Article
- Association of the total cholesterol to high-density lipoprotein cholesterol ratio with all-cause mortality risk in the migraine population.The journal of headache and pain · 2025Article
- The nonlinear association of ratio of total cholesterol to high density lipoprotein with cognition ability: evidence from a community cohort in China.Frontiers in nutrition · 2025Article
- Associations of the Total Cholesterol/high-density Lipoprotein Cholesterol Ratio with Outcomes in Lupus Nephritis.International journal of medical sciences · 2025Article
- Association of atherogenic index of plasma with early-onset post-stroke depression: a prospective study.Frontiers in psychiatry · 2025Article
- Association between atherogenic index of plasma and post-stroke depression: a cross-sectional study.European journal of psychotraumatology · 2024Article
- THR as a Novel Biomarker for Carotid Stenosis Severity in Acute Ischemic Stroke: Implications for Risk Stratification and Personalized Management.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
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6 authors.
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Abstract
objectiveThe connection between total cholesterol to high-density lipoprotein cholesterol (TC/HDL-C) ratio and stroke risk is controversial. This study aims to examine the connection between the TC/HDL-C ratio and stroke in middle-aged and older individuals who are part of the China Health and Retirement Longitudinal Study (CHARLS).
methodsThis study conducted a retrospective cohort analysis, enrolling a total of 10,184 participants who met the designated criteria from CHARLS between 2011 and 2012. We then used the Cox proportional-hazards regression model to analyze the relationship between the TC/HDL-C ratio and stroke risk. Using a Cox proportional hazards regression model with cubic spline functions and smooth curve fitting, we were able to identify the non-linear relationship between the TC/HDL-C ratio and stroke occurrence. The sensitivity and subgroup analyses were also performed to investigate the connection between TC/HDL-C ratio and stroke.
resultsThis study revealed a statistically significant association between the TC/HDL-C ratio and stroke risk in subjects aged 45 years or older after adjusting for risk factors (HR: 1.05, 95%CI 1.00-1.10, P = 0.0410). Furthermore, a non-linear connection between the TC/HDL-C ratio and stroke risk was detected, with a TC/HDL-C ratio inflection point of 3.71. We identified a significant positive connection between the TC/HDL-C ratio and stroke risk, when the TC/HDL-C ratio was less than 3.71 (HR: 1.25, 95%CI 1.07-1.45, P = 0.0039). However, their connection was not significant when the TC/HDL-C ratio exceeded 3.71 (HR: 1.00, 95%CI 0.94-1.06, P = 0.9232). The sensitivity analysis and subgroup analyses revealed that our findings were well-robust.
conclusionOur study demonstrated a positive, non-linear connection between the TC/HDL-C ratio and stroke risk in middle-aged and older individuals. There was a significant positive connection between the TC/HDL-C ratio and stroke risk, when the TC/HDL-C ratio was less than 3.71. The current research can be used as a guideline to support clinician consultation and optimize stroke prevention measures for middle-aged and older adults.
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