Evidence map›Paper›PMID 38491228›Full record

ReviewVirchows Archiv : an international journal of pathology2024

Molecularly defined sinonasal malignancies: an overview with focus on the current WHO classification and recently described provisional entities.

Alena Skálová, Abbas Agaimy, Martina Bradova, Vincent Vander Poorten, Ehab Hanna, Orlando Guntinas-Lichius, Alessandro Franchi, Henrik Hellquist, Roderick H W Simpson, Fernando Lopéz and 7 more

Open access · hybridAbstract readReview
In one paragraph

Review in Virchows Archiv : an international journal of pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  4. Case reports in pathology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 13 institutions in 11 countries.

Alena SkálováSikl's Department of Pathology, Faculty of Medicine in Pilsen, Charles University, E. Benese 13, 305 99, Pilsen, Czech Republic. skalova@biopticka.cz.
Abbas AgaimyInstitute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.
Martina BradovaSikl's Department of Pathology, Faculty of Medicine in Pilsen, Charles University, E. Benese 13, 305 99, Pilsen, Czech Republic.
Vincent Vander PoortenDepartment of Otorhinolaryngology-Head and Neck Surgery, Leuven Cancer Institute, University Hospitals Leuven, 3000, Louvain, Belgium.
Ehab HannaDepartment of Head & Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Orlando Guntinas-LichiusDepartment of Otorhinolaryngology, Jena University Hospital, Jena, Germany.
Alessandro FranchiDepartment of Translational Research, School of Medicine, University of Pisa, Pisa, Italy.
Henrik HellquistFaculty of Medicine and Biomedical Sciences (FMCB), Biomedical Center Research Institute (ABC-RI), University of Algarve, Faro, Portugal.
Roderick H W SimpsonDepartment of Anatomical Pathology, University of Calgary, Calgary, AB, Canada.
Fernando LopézDepartment of Otolaryngology, ISPA, IUOPA, CIBERONC, Hospital Universitario Central de Asturias, University of Oviedo, Oviedo, Spain.
Sandra NuytsLaboratory of Experimental Radiotherapy, Department of Oncology, Leuven Cancer Institute, University Hospitals Leuven, 3000, Louvain, Belgium.
Carlos Chiesa-EstombaDepartment of Otorhinolaryngology-Head and Neck Surgery, Hospital Universitario Donostia, Donostia-San Sebastian, Guipuzkoa-Basque Country, Spain.
Sweet Ping NgDepartment of Radiation Oncology, Olivia Newton-John Cancer Wellness and Research Centre, Austin Health, Melbourne, Australia.
Akihiro HommaDepartment of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, Hokkaido, Japan.
Yong TengDepartment of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.
Ilmo LeivoInstitute of Biomedicine, Pathology, University of Turku, Turku, Finland.
Alfio FerlitoCoordinator of the International Head and Neck Scientific Group, Padua, Italy.
Biopticka Laborator (Czechia) · CZKU Leuven · BEAustin Health · AUEmory University · USFriedrich-Alexander-Universität Erlangen-Nürnberg · DEHokkaido University · JPJena University Hospital · DEThe University of Texas MD Anderson Cancer Center · USUniversidad de Oviedo · ESUniversity of Algarve · PTUniversity of Calgary · CAUniversity of Pisa · ITUniversity of Turku · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Classification of tumors of the head and neck has evolved in recent decades including a widespread application of molecular testing in tumors of the sinonasal tract, salivary glands, and soft tissues with a predilection for the head and neck. The availability of new molecular techniques has allowed for the definition of multiple novel tumor types unique to head and neck sites. Moreover, an expanding spectrum of immunohistochemical markers specific to genetic alterations facilitates rapid identification of diagnostic molecular abnormalities. As such, it is currently possible for head and neck pathologists to benefit from a molecularly defined tumor classification while making diagnoses that are still based largely on histopathology and immunohistochemistry. This review covers the principal molecular alterations in sinonasal malignancies, such as alterations in DEK, AFF2, NUTM1, IDH1-2, and SWI/SNF genes in particular, that are important from a practical standpoint for diagnosis, prognosis, and prediction of response to treatment.

Indexed as

Biomarkers, TumorParanasal Sinus NeoplasmsHumansWorld Health OrganizationBiomarkers, TumorHead and neckMolecular diagnosticsNext-generation sequencingSinonasalSinonasal tumorSoft tissue

Identifiers

PMID38491228
PMCPMC11186917
OpenAlexW4392884522

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.