ArticleScientific reports2024
Development of extended pharmacokinetic models for propofol based on measured blood and brain concentrations.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.
- Target-Controlled Infusion of Propofol: A Systematic Review of Recent Results.Journal of medical systems · 2025Pooled it
- Mechanistic simulation identifies predictive dose-dependent biomarkers of propofol anesthesia.bioRxiv : the preprint server for biology · 2026Article
- Anesthetic-induced neurodevelopmental changes with region-specific responses to propofol in forebrain organoids.Stem cell reports · 2026Article
- ICU patient-on-a-chip emulating orchestration of mast cells and cerebral organoids in neuroinflammation.Communications biology · 2024Article
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
Abstract
Propofol's pharmacokinetics have been extensively studied using human blood samples and applied to target-controlled infusion systems; however, information on its concentration in the brain remains scarce. Therefore, this study aimed to simultaneously measure propofol plasma and brain concentrations in patients who underwent awake craniotomy and establish new pharmacokinetic model. Fifty-seven patients with brain tumors or brain lesions who underwent awake craniotomy were sequentially assigned to model-building and validating groups. Plasma and brain (lobectomy or uncapping margins) samples were collected at five time-points. The concentration of propofol was measured using high-performance liquid chromatography. Population pharmacokinetic analysis was conducted through a nonlinear mixed-effects modeling program using a first-order conditional estimation method with interactions. Propofol's brain concentrations were higher than its plasma concentrations. The measured brain concentrations were higher than the effect site concentrations using the previous models. Extended models were constructed based on measured concentrations by incorporating the brain/plasma partition coefficient (K
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Registered trials
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