SynthesisNature human behaviour2024
The neuroanatomy of developmental language disorder: a systematic review and meta-analysis.
Synthesis in Nature human behaviour, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- [Association between auditory processing and behavioral problems in preschool children with developmental language disorder].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- Structural and functional connectivity in infancy relate to communication skills at age 2 in children born very preterm.medRxiv : the preprint server for health sciences · 2026Article
- Influence of Semantic Richness on Word Form Learning in Children With Developmental Language Disorder.Journal of speech, language, and hearing research : JSLHR · 2026Article
- Ancient regulatory evolution shapes individual language abilities in present-day humans.Science advances · 2026Article
- Many Moving Parts: A Motor-Based Perspective on Developmental Speech and Language Research in Neurodevelopmental Disorders.Journal of speech, language, and hearing research : JSLHR · 2026Article
- Ancient regulatory evolution shapes individual language abilities in present-day humans.bioRxiv : the preprint server for biology · 2026Article
- The Neural Cost of Language Processing: Broader Network Recruitment in Adults With Developmental Language Disorder.Neurobiology of language (Cambridge, Mass.) · 2026Article
- Subcortical correlates of developmental language disorder: more than the neostriatum.Brain communications · 2026Article
- Developmental Language Disorder as a Multidimensional Neurodevelopmental Spectrum: Implications for Diagnosis.Journal of speech, language, and hearing research : JSLHR · 2025Review
- Structural and pragmatic language skills in school-age children relate to resting state functional connectivity.Brain imaging and behavior · 2025Article
- Initial evidence of altered functional network connectivity in children with developmental language disorder.Brain and language · 2025Article
- Children with lower language skill engage additional brain mechanisms in both hemispheres during sentence comprehension.Research square · 2025Article
- An approach to measuring language-specific brain function in developmental language disorder.Acta psychologica · 2025Article
- Examining the role of phonological and semantic mechanisms during morphological processing of sentences in 7-year-old children.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Subcortical brain iron and its link to verbal memory in children with developmental language disorder.Brain and language · 2025Article
- Processing of Scene-Grammar Inconsistencies in Children with Developmental Language Disorder-Insights from Implicit and Explicit Measures.Brain sciences · 2025Article
- Subcortical Brain Volumes and Neurocognitive Function in Children With Perinatal HIV Exposure: A Population-Based Cohort Study in South Africa.Open forum infectious diseases · 2024Article
- The shared neurobiological basis of developmental dyslexia and developmental stuttering: A meta-analysis of functional and structural MRI studies.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
Developmental language disorder (DLD) is a common neurodevelopmental disorder with adverse impacts that continue into adulthood. However, its neural bases remain unclear. Here we address this gap by systematically identifying and quantitatively synthesizing neuroanatomical studies of DLD using co-localization likelihood estimation, a recently developed neuroanatomical meta-analytic technique. Analyses of structural brain data (22 peer-reviewed papers, 577 participants) revealed highly consistent anomalies only in the basal ganglia (100% of participant groups in which this structure was examined, weighted by group sample sizes; 99.8% permutation-based likelihood the anomaly clustering was not due to chance). These anomalies were localized specifically to the anterior neostriatum (again 100% weighted proportion and 99.8% likelihood). As expected given the task dependence of activation, functional neuroimaging data (11 peer-reviewed papers, 414 participants) yielded less consistency, though anomalies again occurred primarily in the basal ganglia (79.0% and 95.1%). Multiple sensitivity analyses indicated that the patterns were robust. The meta-analyses elucidate the neuroanatomical signature of DLD, and implicate the basal ganglia in particular. The findings support the procedural circuit deficit hypothesis of DLD, have basic research and translational implications for the disorder, and advance our understanding of the neuroanatomy of language.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.