Evidence map›Paper›PMID 38491011›Full record

SynthesisNature communications2024

Uptake of COVID-19 vaccinations amongst 3,433,483 children and young people: meta-analysis of UK prospective cohorts.

Sarah J Aldridge, Utkarsh Agrawal, Siobhán Murphy, Tristan Millington, Ashley Akbari, Fatima Almaghrabi, Sneha N Anand, Stuart Bedston, Rosalind Goudie, Rowena Griffiths and 10 more

Open access · goldAbstract readMeta-Analysis
In one paragraph

Synthesis in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
9.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Review
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  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 1 country.

Sarah J AldridgePopulation Data Science, Swansea University Medical School, Faculty of Medicine, Health, and Life Science, Swansea University, Swansea, UK. s.j.aldridge@swansea.ac.uk.ORCID 0000-0002-5158-1242
Utkarsh AgrawalNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Siobhán MurphyCentre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK.
Tristan MillingtonUsher Institute, University of Edinburgh, Edinburgh, UK.
Ashley AkbariPopulation Data Science, Swansea University Medical School, Faculty of Medicine, Health, and Life Science, Swansea University, Swansea, UK.ORCID 0000-0003-0814-0801
Fatima AlmaghrabiUsher Institute, University of Edinburgh, Edinburgh, UK.
Sneha N AnandNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Stuart BedstonPopulation Data Science, Swansea University Medical School, Faculty of Medicine, Health, and Life Science, Swansea University, Swansea, UK.
Rosalind GoudieNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Rowena GriffithsPopulation Data Science, Swansea University Medical School, Faculty of Medicine, Health, and Life Science, Swansea University, Swansea, UK.
Mark JoyNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Emily LowthianDepartment of Education and Childhood Studies, School of Social Sciences, Swansea University, Swansea, UK.
Simon de LusignanNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.ORCID 0000-0002-8553-2641
Lynsey PattersonCentre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK.
Chris RobertsonDepartment of Mathematics and Statistics, Strathclyde University, Glasgow, UK and Public Health Scotland, Glasgow, UK.ORCID 0000-0001-6848-5241
Igor RudanCentre for Global Health, Usher Institute, the University of Edinburgh, Edinburgh, UK.
Declan T BradleyCentre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK.ORCID 0000-0003-1468-1823
Ronan A LyonsPopulation Data Science, Swansea University Medical School, Faculty of Medicine, Health, and Life Science, Swansea University, Swansea, UK.ORCID 0000-0001-5225-000X
Aziz SheikhNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Rhiannon K OwenPopulation Data Science, Swansea University Medical School, Faculty of Medicine, Health, and Life Science, Swansea University, Swansea, UK. r.k.owen@swansea.ac.uk.ORCID 0000-0001-5977-376X
Swansea University · GBUniversity of Oxford · GBQueen's University Belfast · GBUniversity of Edinburgh · GBUniversity of Strathclyde · GB

Funding

Diabetes UK SBF006\1122Medical Research Council MC_PC_20058
6 · The paper itself

Abstract

SARS-CoV-2 infection in children and young people (CYP) can lead to life-threatening COVID-19, transmission within households and schools, and the development of long COVID. Using linked health and administrative data, we investigated vaccine uptake among 3,433,483 CYP aged 5-17 years across all UK nations between 4th August 2021 and 31st May 2022. We constructed national cohorts and undertook multi-state modelling and meta-analysis to identify associations between demographic variables and vaccine uptake. We found that uptake of the first COVID-19 vaccine among CYP was low across all four nations compared to other age groups and diminished with subsequent doses. Age and vaccination status of adults living in the same household were identified as important risk factors associated with vaccine uptake in CYP. For example, 5-11 year-olds were less likely to receive their first vaccine compared to 16-17 year-olds (adjusted Hazard Ratio [aHR]: 0.10 (95%CI: 0.06-0.19)), and CYP in unvaccinated households were less likely to receive their first vaccine compared to CYP in partially vaccinated households (aHR: 0.19, 95%CI 0.13-0.29).

Indexed as

COVID-19COVID-19 VaccinesAdolescentChildChild, PreschoolHumansPost-Acute COVID-19 SyndromeProspective StudiesSARS-CoV-2United KingdomVaccinationCOVID-19 Vaccines

Identifiers

PMID38491011
PMCPMC10943015
OpenAlexW4392865253

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.