Evidence map›Paper›PMID 38491006›Full record

ArticleNature communications2024

Complexes of tubulin oligomers and tau form a viscoelastic intervening network cross-bridging microtubules into bundles.

Phillip A Kohl, Chaeyeon Song, Bretton J Fletcher, Rebecca L Best, Christine Tchounwou, Ximena Garcia Arceo, Peter J Chung, Herbert P Miller, Leslie Wilson, Myung Chul Choi and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Capillary bundling of microtubules by condensates.bioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Phillip A Kohl *Materials Research Laboratory, University of California, Santa Barbara, Santa Barbara, CA, 93106, USA.
Chaeyeon Song *Materials Department, University of California, Santa Barbara, Santa Barbara, CA, 93106, USA.
Bretton J Fletcher *Materials Department, University of California, Santa Barbara, Santa Barbara, CA, 93106, USA.
Rebecca L BestDepartment of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, USA.ORCID 0000-0001-7183-879X
Christine TchounwouMaterials Department, University of California, Santa Barbara, Santa Barbara, CA, 93106, USA.
Ximena Garcia ArceoDepartment of Physics, University of California, Santa Barbara, Santa Barbara, CA, 93106, USA.
Peter J ChungMaterials Department, University of California, Santa Barbara, Santa Barbara, CA, 93106, USA.ORCID 0000-0002-5187-8281
Herbert P MillerDepartment of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, USA.
Leslie WilsonDepartment of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, USA.
Myung Chul ChoiDepartment of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Daejeon, 34141, Korea.
Youli LiMaterials Research Laboratory, University of California, Santa Barbara, Santa Barbara, CA, 93106, USA. youli@mrl.ucsb.edu.ORCID 0000-0001-5117-3874
Stuart C FeinsteinDepartment of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, USA.
Cyrus R SafinyaMaterials Department, University of California, Santa Barbara, Santa Barbara, CA, 93106, USA. cyrussafinya@ucsb.edu.ORCID 0000-0002-3295-7128
University of California, Santa Barbara · USKorea Advanced Institute of Science and Technology · KRUniversity of Southern California · US

Funding

The Molecular Structure and Function of Tau ProteinR01NS035010 · NINDS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI FEINSTEIN, STUART C · 1996 to 2010
$2.7M
National Science Foundation (NSF) DMR-1807327NINDS NIH HHS R01 NS035010U.S. Department of Energy (DOE) DE-FG02-06ER46314
6 · The paper itself

Abstract

The axon-initial-segment (AIS) of mature neurons contains microtubule (MT) fascicles (linear bundles) implicated as retrograde diffusion barriers in the retention of MT-associated protein (MAP) tau inside axons. Tau dysfunction and leakage outside of the axon is associated with neurodegeneration. We report on the structure of steady-state MT bundles in varying concentrations of Mg

Indexed as

tau ProteinsTubulinHumansMicrotubulesScattering, Small AngleX-Ray DiffractionMAPT protein, humantau ProteinsTubulin

Identifiers

PMID38491006
PMCPMC10943092
OpenAlexW4392865268

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.