Evidence map›Paper›PMID 38490824›Full record

ArticleVaccine2024

The effect of SARS-COV-2 variant on non-respiratory features and mortality among vaccinated and non-fully vaccinated patients.

Shannon A Cotton, Ajan Subramanian, Thomas D Hughes, Yong Huang, Carmen Josefa Sierra, Alex K Pearce, Atul Malhotra, Amir M Rahmani, Charles A Downs, Melissa D Pinto

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shannon A CottonUniversity of California, Irvine, School of Nursing, 854 Health Sciences Rd, Irvine, CA 92697, USA; University of California, Irvine, Department of Computer Science, Donald Bren Hall, 6210, Irvine, CA 92697, USA. Electronic address: sacotton@uci.edu.
Ajan SubramanianUniversity of California, Irvine, Department of Computer Science, Donald Bren Hall, 6210, Irvine, CA 92697, USA. Electronic address: ajans1@uci.edu.
Thomas D HughesUniversity of California, Irvine, School of Nursing, 854 Health Sciences Rd, Irvine, CA 92697, USA. Electronic address: thomasdh@health.uci.edu.
Yong HuangUniversity of California, Irvine, Department of Computer Science, Donald Bren Hall, 6210, Irvine, CA 92697, USA. Electronic address: yongh7@uci.edu.
Carmen Josefa SierraUniversity of Miami Florida, School of Nursing, 5030 Brunson Dr, Coral Gables, FL 33146, USA. Electronic address: carmenjsierra@miami.edu.
Alex K PearceUniversity of California, San Diego, Dept of Pulmonary and Critical Care Medicine, 9300 Campus Point Dr, La Jolla, CA 92037, USA. Electronic address: apearce@health.ucsd.edu.
Atul MalhotraUniversity of California, San Diego, Dept of Pulmonary and Critical Care Medicine, 9300 Campus Point Dr, La Jolla, CA 92037, USA. Electronic address: amalhotra@health.ucsd.edu.
Amir M RahmaniUniversity of California, Irvine, School of Nursing, 854 Health Sciences Rd, Irvine, CA 92697, USA; University of California, Irvine, Department of Computer Science, Donald Bren Hall, 6210, Irvine, CA 92697, USA. Electronic address: a.rahmani@uci.edu.
Charles A DownsUniversity of Miami Florida, School of Nursing, 5030 Brunson Dr, Coral Gables, FL 33146, USA. Electronic address: cxd826@miami.edu.
Melissa D PintoUniversity of California, Irvine, School of Nursing, 854 Health Sciences Rd, Irvine, CA 92697, USA. Electronic address: mdpinto@uci.edu.

Funding

Is Obstructive Sleep Apnea Important in the Development of Alzheimer's DiseaseR01AG063925 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2020 to 2024
$3.7M
Underlying mechanisms of obesity-induced obstructive sleep apneaR01HL148436 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Atul Malhotra · 2020 to 2026
$3.4M
Sleep Apnea Endophenotypes: One Size Does Not Fit AllR01HL154926 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2021 to 2025
$3.3M
The cardiovascular consequences of sleep apnea plus COPD (Overlap syndrome)R01HL166485 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Atul Malhotra · 2023 to 2026
$3.1M
VentNet: A Real-Time Multimodal Data Integration Model for Prediction of Respiratory Failure in Patients with COVID-19R01HL157985 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, NEMATI, SHAMIM · 2022 to 2025
$2.9M
Developing a Diverse Next Generation of Leaders in Respiratory ScienceT32HL166127 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Laura Elise Crotty Alexander, Atul Malhotra · 2023 to 2026
$1.6M
NHLBI NIH HHS R01 HL148436NHLBI NIH HHS R01 HL154926NHLBI NIH HHS R01 HL157985NHLBI NIH HHS R01 HL166485NHLBI NIH HHS T32 HL166127NIA NIH HHS R01 AG063925
6 · The paper itself

Abstract

objectiveTo determine the effect of SARS-CoV-2 variants on non-respiratory features of COVID-19 in vaccinated and not fully vaccinated patients using a University of California database.

methodsA longitudinal retrospective review of medical records (n = 63,454) from 1/1/2020-4/26/2022 using the UCCORDS database was performed to compare non-respiratory features, vaccination status, and mortality between variants. Chi-square tests were used to study the relationship between categorical variables using a contingency matrix.

resultsFever was the most common feature across all variants. Fever was significantly higher in not fully vaccinated during the Delta and Omicron waves (p = 0.001; p = 0.001). Cardiac features were statistically higher in not fully vaccinated during Omicron; tachycardia was only a feature of not fully vaccinated during Delta and Omicron; diabetes and GI reflux were features of all variants regardless of vaccine status. Odds of death were significantly increased among those not fully vaccinated in the Delta and Omicron variants (Delta OR: 1.64, p = 0.052; Omicron OR: 1.96, p < 0.01). Vaccination was associated with a decrease in the frequency of non-respiratory features.

conclusionsRisk of non-respiratory features of COVID-19 is statistically higher in those not fully vaccinated across all variants. Risk of death and correlation with vaccination status varied.

Indexed as

COVID-19SARS-CoV-2Databases, FactualFeverHumansCOVID-19COVID-19 mortalityNon-respiratoryOrgan dysfunctionSymptomsVaccination

Identifiers

PMID38490824
PMCPMC11182488

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.