Evidence map›Paper›PMID 38489371›Full record

ArticleScience advances2024

Increased genomic instability and reshaping of tissue microenvironment underlie oncogenic properties of

Alessandro D'Ambrosio, Davide Bressan, Elisa Ferracci, Francesco Carbone, Patrizia Mulè, Federico Rossi, Caterina Barbieri, Elisa Sorrenti, Gaia Fiaccadori, Thomas Detone and 11 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. ARID1A and Its Impact Across the Hallmarks of Cancer.International journal of molecular sciences · 2025
    Review
  7. Chromatin remodellers as therapeutic targets.Nature reviews. Drug discovery · 2024
    Review
  8. Article
  9. Cancers · 2024
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 7 institutions in 2 countries.

Alessandro D'AmbrosioLaboratory of stem cells and cancer genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy.ORCID 0000-0001-5926-974X
Davide BressanLaboratory of stem cells and cancer genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy.ORCID 0000-0003-4757-2535
Elisa FerracciLaboratory of stem cells and cancer genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy.ORCID 0000-0003-2515-0518
Francesco CarboneUnità Operativa Multizonale di Anatomia Patologica, APSS, 38122 Trento, Italy.ORCID 0000-0001-8425-9658
Patrizia MulèDepartment of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, 20139 Milan, Italy.ORCID 0000-0002-7030-5008
Federico RossiDepartment of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, 20139 Milan, Italy.
Caterina BarbieriDepartment of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, 20139 Milan, Italy.
Elisa SorrentiLaboratory of stem cells and cancer genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy.ORCID 0000-0002-3905-647X
Gaia FiaccadoriLaboratory of stem cells and cancer genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy.ORCID 0009-0002-8803-1006
Thomas DetoneUnità Operativa Multizonale di Anatomia Patologica, APSS, 38122 Trento, Italy.ORCID 0009-0003-5181-7694
Elena VezzoliDepartment of Biomedical sciences for Health, University of Milan, 20133 Milan, Italy.ORCID 0000-0002-3342-3451
Salvatore BianchiCenter for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT), 20139 Milan, Italy.ORCID 0009-0009-7383-9732
Chiara SartoriUnità Operativa Multizonale di Anatomia Patologica, APSS, 38122 Trento, Italy.ORCID 0000-0003-3137-0082
Simona CorsoDepartment of Oncology, University of Torino, 10060 Candiolo, Italy.ORCID 0000-0002-5069-1503
Akihisa FukudaDepartment of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.ORCID 0000-0002-1940-596X
Giovanni BertalotUnità Operativa Multizonale di Anatomia Patologica, APSS, 38122 Trento, Italy.ORCID 0000-0002-4862-7705
Andrea FalquiDepartment of Physics, University of Milan, 20133 Milan, Italy.ORCID 0000-0002-1476-7742
Mattia BarbareschiUnità Operativa Multizonale di Anatomia Patologica, APSS, 38122 Trento, Italy.ORCID 0000-0003-0217-3223
Alessandro RomanelLaboratory of Bioinformatics and Computational Genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy.ORCID 0000-0003-4855-8620
Diego PasiniDepartment of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, 20139 Milan, Italy.ORCID 0000-0002-9879-6486
Fulvio ChiacchieraLaboratory of stem cells and cancer genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy.ORCID 0000-0003-3830-2090
University of Trento · ITEuropean Institute of Oncology · ITProvincia Autonoma di Trento · ITUniversity of Milan · ITCandiolo Cancer Institute · ITItalian Institute of Technology · ITKyoto University · JP

Funding

European Research Council
6 · The paper itself

Abstract

Oncogenic mutations accumulating in many chromatin-associated proteins have been identified in different tumor types. With a mutation rate from 10 to 57%,

Indexed as

NeoplasmsNuclear ProteinsAnimalsDNA-Binding ProteinsGenomic InstabilityHumansMiceMutationMutation RateTranscription FactorsTumor MicroenvironmentARID1A protein, humanDNA-Binding ProteinsNuclear ProteinsTranscription Factors

Identifiers

PMID38489371
PMCPMC10942108
OpenAlexW4392857147

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.