Evidence map›Paper›PMID 38489350›Full record

ArticleScience immunology2024

RORγt up-regulates RAG gene expression in DP thymocytes to expand the

Abani Kanta Naik, Danielle J Dauphars, Elizabeth Corbett, Lunden Simpson, David G Schatz, Michael S Krangel

Open access · greenAbstract read
In one paragraph

Article in Science immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Preselection CD4bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Abani Kanta NaikDepartment of Integrative Immunobiology, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0001-9032-1147
Danielle J DaupharsDepartment of Integrative Immunobiology, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0003-4167-7491
Elizabeth CorbettDepartment of Immunobiology and Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT, USA.
Lunden SimpsonDepartment of Integrative Immunobiology, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0002-7556-1078
David G SchatzDepartment of Immunobiology and Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-5669-1176
Michael S KrangelDepartment of Integrative Immunobiology, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0003-1292-254X
Duke University · USYale University · US

Funding

Mechanism and Targeting of V(D)J RecombinationR01AI032524 · NIAID · YALE UNIVERSITY · PI David G. Schatz · 1992 to 2026
$6.7M
Basic Immunology Training ProgramT32AI052077 · NIAID · DUKE UNIVERSITY · PI KRANGEL, MICHAEL S · 2002 to 2024
$4.2M
Chromatin regulation of TCR locus V(D)J recombinationR35GM136284 · NIGMS · DUKE UNIVERSITY · PI KRANGEL, MICHAEL S · 2020 to 2024
$2.4M
NIAID NIH HHS R01 AI032524NIAID NIH HHS T32 AI052077NIGMS NIH HHS R35 GM136284
6 · The paper itself

Abstract

Recombination activating gene (RAG) expression increases as thymocytes transition from the CD4

Indexed as

Nuclear Receptor Subfamily 1, Group F, Member 3ThymocytesAnimalsGene ExpressionGenes, RAG-1MiceReceptors, Antigen, T-Cell, alpha-betaTranscription FactorsNuclear Receptor Subfamily 1, Group F, Member 3Receptors, Antigen, T-Cell, alpha-betaRorc protein, mouseTranscription Factors

Identifiers

PMID38489350
PMCPMC11005092
OpenAlexW4392861846

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.