Evidence map›Paper›PMID 38489267›Full record

ArticleCell reports2024

Relapse to cocaine seeking is regulated by medial habenula NR4A2/NURR1 in mice.

Jessica E Childs, Samuel Morabito, Sudeshna Das, Caterina Santelli, Victoria Pham, Kelly Kusche, Vanessa Alizo Vera, Fairlie Reese, Rianne R Campbell, Dina P Matheos and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Regulation ofInternational journal of molecular sciences · 2025
    Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Jessica E ChildsDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA; UC Irvine Center for Addiction Neuroscience, School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory, School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA.
Samuel MorabitoInstitute for Memory Impairments and Neurological Disorders (MIND), University of California, Irvine, Irvine, CA 92697, USA; Mathematical, Computational, and Systems Biology (MCSB) Program, University of California, Irvine, Irvine, CA 92697, USA; Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697, USA.
Sudeshna DasDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA; Institute for Memory Impairments and Neurological Disorders (MIND), University of California, Irvine, Irvine, CA 92697, USA.
Caterina SantelliDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA; UC Irvine Center for Addiction Neuroscience, School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory, School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA.
Victoria PhamDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA; UC Irvine Center for Addiction Neuroscience, School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory, School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA.
Kelly KuscheDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA; UC Irvine Center for Addiction Neuroscience, School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory, School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA.
Vanessa Alizo VeraDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA; UC Irvine Center for Addiction Neuroscience, School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory, School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA.
Fairlie ReeseCenter for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697, USA; Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA.
Rianne R CampbellDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA; UC Irvine Center for Addiction Neuroscience, School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory, School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA.
Dina P MatheosDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA; UC Irvine Center for Addiction Neuroscience, School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory, School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA.
Vivek SwarupDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA; Institute for Memory Impairments and Neurological Disorders (MIND), University of California, Irvine, Irvine, CA 92697, USA. Electronic address: vswarup@uci.edu.
Marcelo A WoodDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA; UC Irvine Center for Addiction Neuroscience, School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory, School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA; Institute for Memory Impairments and Neurological Disorders (MIND), University of California, Irvine, Irvine, CA 92697, USA. Electronic address: mwood@uci.edu.
University of California, Irvine · US

Funding

Mechanisms of maladaptive memory formation and suppression in a preclinical model of the comorbidity between PTSD and addictionR01DA047981 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI LATTAL, K MATTHEW, WOOD, MARCELO ANDRES · 2019 to 2023
$3.7M
Dynamic epigenomic landscape of opioid abuse following early-life adversityU01DA053826 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Tallie Z. Baram, CHRISTIE D FOWLER · 2022 to 2026
$3.4M
Epigenetic mechanisms in the medial habenula governing drug-seeking behaviorR01DA047441 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI LYNCH, GARY S, WOOD, MARCELO ANDRES · 2020 to 2024
$3.3M
Oligodendrocyte heterogeneity in Alzheimer' s diseaseRF1AG071683 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI SWARUP, VIVEK, ZHANG, JING · 2021 to 2024
$2.2M
Oligodendrocyte heterogeneity in Alzheimer' s diseaseR01AG071683 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI SWARUP, VIVEK · 2024 to 2025
$1.2M
Relapse to drug-seeking behavior is regulated by medial habenula NR4A2 in male and female miceF32DA055438 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHILDS, JESSICA ERIN · 2022 to 2023
$144k
Epigenetic Mechanisms Underlying Drug-seeking Behavior: Role of HDAC3 in Regulating Gene Expression within the MHb Cholinergic Population for Cocaine-induced Relapse-like BehaviorF31DA059982 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI ALIZO VERA, VANESSA · 2024 to 2024
$45k
NIA NIH HHS R01 AG071683NIA NIH HHS RF1 AG071683NIDA NIH HHS F31 DA059982NIDA NIH HHS F32 DA055438NIDA NIH HHS R01 DA047441NIDA NIH HHS R01 DA047981NIDA NIH HHS U01 DA053826
6 · The paper itself

Abstract

Drugs of abuse can persistently change the reward circuit in ways that contribute to relapse behavior, partly via mechanisms that regulate chromatin structure and function. Nuclear orphan receptor subfamily4 groupA member2 (NR4A2, also known as NURR1) is an important effector of histone deacetylase 3 (HDAC3)-dependent mechanisms in persistent memory processes and is highly expressed in the medial habenula (MHb), a region that regulates nicotine-associated behaviors. Here, expressing the Nr4a2 dominant negative (Nurr2c) in the MHb blocks reinstatement of cocaine seeking in mice. We use single-nucleus transcriptomics to characterize the molecular cascade following Nr4a2 manipulation, revealing changes in transcriptional networks related to addiction, neuroplasticity, and GABAergic and glutamatergic signaling. The network controlled by NR4A2 is characterized using a transcription factor regulatory network inference algorithm. These results identify the MHb as a pivotal regulator of relapse behavior and demonstrate the importance of NR4A2 as a key mechanism driving the MHb component of relapse.

Indexed as

CocaineHabenulaAnimalsGene Expression RegulationMemoryMiceRecurrenceCocaineaddictioncocaineCP: Neurosciencelearning and memorymedial habenulaNr4a2Nurr1relapseself-administrationsingle-nucleus RNA sequencingsubstance use disordertranscription factor regulatory network

Identifiers

PMID38489267
PMCPMC11100346
OpenAlexW4392814089

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.