Evidence map›Paper›PMID 38489034›Full record

ArticleEuropean journal of applied physiology2024

Hemorrhage at high altitude: impact of sustained hypobaric hypoxia on cerebral blood flow, tissue oxygenation, and tolerance to simulated hemorrhage in humans.

Alexander J Rosenberg, Garen K Anderson, Haley J McKeefer, Jordan Bird, Brandon Pentz, Britta R M Byman, Nicholas Jendzjowsky, Richard J Wilson, Trevor A Day, Caroline A Rickards

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of applied physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Alexander J Rosenberg *Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, USA.
Garen K Anderson *Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, USA.
Haley J McKeeferDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, USA.
Jordan BirdMount Royal University, Calgary, AB, Canada.
Brandon PentzMount Royal University, Calgary, AB, Canada.
Britta R M BymanMount Royal University, Calgary, AB, Canada.
Nicholas JendzjowskyUniversity of Calgary, Calgary, AB, Canada.
Richard J WilsonUniversity of Calgary, Calgary, AB, Canada.
Trevor A DayMount Royal University, Calgary, AB, Canada.
Caroline A RickardsDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, USA. caroline.rickards@unthsc.edu.ORCID http://orcid.org/0000-0002-5759-6912
Mount Royal University · CAUniversity of North Texas · USUniversity of Calgary · CA

Funding

Training in the Neurobiology of Aging and Alzheimer's DiseaseT32AG020494 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI ROBERT Clinton BARBER, NATHALIE SUMIEN · 2002 to 2026
$6.9M
Development of a clinically-relevant test for assessment of cerebral vascular functionF32HL144082 · NHLBI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI ROSENBERG, ALEXANDER · 2019 to 2021
$149k
American Heart Association 17GRNT33671110American Heart Association 20PRE35210249American Heart Association-American Stroke Association 17GRNT33671110Natural Sciences and Engineering Research Council of Canada Discovery Grant RGPIN-2016-04915NHLBI NIH HHS F32 HL144082NIA NIH HHS T32 AG020494NIH HHS T32 AG020494Ruth L. Kirchstein NRSA F32 Postdoctoral Fellowship 1F32 HL144082-01A11F32 HL144082-01A1
6 · The paper itself

Abstract

With ascent to high altitude (HA), compensatory increases in cerebral blood flow and oxygen delivery must occur to preserve cerebral metabolism and consciousness. We hypothesized that this compensation in cerebral blood flow and oxygen delivery preserves tolerance to simulated hemorrhage (via lower body negative pressure, LBNP), such that tolerance is similar during sustained exposure to HA vs. low altitude (LA). Healthy humans (4F/4 M) participated in LBNP protocols to presyncope at LA (1130 m) and 5-7 days following ascent to HA (3800 m). Internal carotid artery (ICA) blood flow, cerebral delivery of oxygen (CDO

Indexed as

AltitudeCerebrovascular CirculationAdultCarotid Artery, InternalFemaleHemorrhageHumansHypoxiaLower Body Negative PressureMaleOxygenOxygen ConsumptionOxygen SaturationOxygenCentral hypovolemiaCerebral blood velocityHypoxiaInternal carotid artery blood flowLower body negative pressure

Identifiers

PMID38489034
PMCPMC11321930
OpenAlexW4392864444

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.