ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024
In Vivo Intelligent Fluorescence Endo-Microscopy by Varifocal Meta-Device and Deep Learning.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Varifocal Alvarez metalens array for adaptive light-field imaging.Nature communications · 2026Article
- Neural phase microscopy with metasurface optics for real-time and nanoscale quantitative phase imaging.Nature communications · 2026Article
- Varifocal Meta-Lens for Multifunctional Focusing and Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Large-gap cascaded Moiré metasurfaces enabling switchable bright-field and phase-contrast imaging compatible with coherent and incoherent light.Nanophotonics (Berlin, Germany) · 2025Article
- Metasurface-based Fourier ptychographic microscopy.Nanophotonics (Berlin, Germany) · 2025Article
- Review for optical metalens based on metasurfaces: fabrication and applications.Microsystems & nanoengineering · 2025Review
- Water-Immersed GaP Huygens' Meta-Optics for Visible Structured Light Generation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Metalens-Based Dual Light-Sheet Fluorescence Microscopy.Small methods · 2025Article
- Quantitative Phase Imaging with a Meta-Based Interferometric System.ACS applied materials & interfaces · 2025Article
- Inverse-designed large field-of-view polychromatic metalens for tri-color scanning fiber endoscopy.Communications engineering · 2025Article
- A Review of Cascaded Metasurfaces for Advanced Integrated Devices.Micromachines · 2024Review
- In Vivo Intelligent Fluorescence Endo-Microscopy by Varifocal Meta-Device and Deep Learning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Endo-microscopy is crucial for real-time 3D visualization of internal tissues and subcellular structures. Conventional methods rely on axial movement of optical components for precise focus adjustment, limiting miniaturization and complicating procedures. Meta-device, composed of artificial nanostructures, is an emerging optical flat device that can freely manipulate the phase and amplitude of light. Here, an intelligent fluorescence endo-microscope is developed based on varifocal meta-lens and deep learning (DL). The breakthrough enables in vivo 3D imaging of mouse brains, where varifocal meta-lens focal length adjusts through relative rotation angle. The system offers key advantages such as invariant magnification, a large field-of-view, and optical sectioning at a maximum focal length tuning range of ≈2 mm with 3 µm lateral resolution. Using a DL network, image acquisition time and system complexity are significantly reduced, and in vivo high-resolution brain images of detailed vessels and surrounding perivascular space are clearly observed within 0.1 s (≈50 times faster). The approach will benefit various surgical procedures, such as gastrointestinal biopsies, neural imaging, brain surgery, etc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.