Evidence map›Paper›PMID 38488356›Full record

ArticleJournal of bacteriology2024

Peeling the onion: additional layers of regulation in the acid stress response.

Linda J Kenney

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bacteriology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Linda J KenneyDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch Galveston, Galveston, Texas, USA.ORCID 0000-0002-8658-0717

Funding

MOLECULAR CHARACTERIZATION OF PORIN GENE REGULATIONR01GM058746 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KENNEY, LINDA J. · 2000 to 2010
$2.3M
Dual Roles for the Salmonella SPI-2 Regulator SsrBR21AI123640 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KENNEY, LINDA J. · 2016 to 2017
$422k
OmpR and SsrB Regulation of Salmonella VirulenceI01BX000372 · VA · JESSE BROWN VA MEDICAL CENTER · PI KENNEY, LINDA J. · 2009 to 2017
–
BLRD VA I01 BX000372NIAID NIH HHS R21 AI123640NIGMS NIH HHS R01 GM058746
6 · The paper itself

Abstract

Bacteria are capable of withstanding large changes in osmolality and cytoplasmic pH, unlike eukaryotes that tightly regulate their pH and cellular composition. Previous studies on the bacterial acid stress response described a rapid, brief acidification, followed by immediate recovery. More recent experiments with better pH probes have imaged single living cells, and we now appreciate that following acid stress, bacteria maintain an acidic cytoplasm for as long as the stress remains. This acidification enables pathogens to sense a host environment and turn on their virulence programs, for example, enabling survival and replication within acidic vacuoles. Single-cell analysis identified an intracellular pH threshold of ~6.5. Acid stress reduces the internal pH below this threshold, triggering the assembly of a type III secretion system in

Indexed as

Escherichia coliEscherichia coli ProteinsAcidsBacterial ProteinsCytoplasmOnionsRepressor ProteinsRNA-Binding ProteinsSalmonellaVacuolesAcidsBacterial ProteinsCsrA protein, E coliEscherichia coli ProteinsRepressor ProteinsRNA-Binding Proteinsacid stress responseamino acid decarboxylationcarbon storage regulationCsrASalmonella pathogenicity island 2SsrBtwo-component regulatory systems

Identifiers

PMID38488356
PMCPMC11025319

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.