Evidence map›Paper›PMID 38488341›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

An Antibiotic Nanobomb Constructed from pH-Responsive Chemical Bonds in Metal-Phenolic Network Nanoparticles for Biofilm Eradication and Corneal Ulcer Healing.

Qiang Gao, Xiaoying Chu, Jie Yang, Yishun Guo, Hanwen Guo, Siyuan Qian, Ying-Wei Yang, Bailiang Wang

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
16.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
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  4. CuJournal of nanobiotechnology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Qiang GaoNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325000, P. R. China.
Xiaoying ChuNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325000, P. R. China.
Jie YangSchool of Life Sciences, Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.
Yishun GuoNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325000, P. R. China.
Hanwen GuoNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325000, P. R. China.
Siyuan QianNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325000, P. R. China.
Ying-Wei YangCollege of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.ORCID 0000-0001-8839-8161
Bailiang WangNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325000, P. R. China.
Wenzhou Medical University · CNJilin University · CNNational Medical Products Administration · CN

Funding

Natural Science Foundation of Zhejiang Province LR21H180001Wenzhou key program of scientific and technological innovation ZY2019017Zhejiang Provincial Traditional Chinese Medicine Science and Technology Project 2021ZA091
6 · The paper itself

Abstract

In the treatment of refractory corneal ulcers caused by Pseudomonas aeruginosa, antibacterial drugs delivery faces the drawbacks of low permeability and short ocular surface retention time. Hence, novel positively-charged modular nanoparticles (NPs) are developed to load tobramycin (TOB) through a one-step self-assembly method based on metal-phenolic network and Schiff base reaction using 3,4,5-trihydroxybenzaldehyde (THBA), ε-poly-ʟ-lysine (EPL), and Cu

Indexed as

Anti-Bacterial AgentsBiofilmsCorneal UlcerDisease Models, AnimalNanoparticlesPseudomonas aeruginosaTobramycinAnimalsDrug Delivery SystemsHydrogen-Ion ConcentrationPseudomonas InfectionsWound HealingAnti-Bacterial AgentsTobramycinantibacterialcorneal ulcersmetal‐phenolic networkmodular assemblypH responsiveness

Identifiers

PMID38488341
PMCPMC11165475
OpenAlexW4392884913

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.