ArticleThe Journal of clinical endocrinology and metabolism2024
Moderate-intensity Combined Training Induces Lipidomic Changes in Individuals With Obesity and Type 2 Diabetes.
Article in The Journal of clinical endocrinology and metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Comparative effectiveness of various combined interventions for type 2 diabetes and obesity: a systematic review and network meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Moderate-intensity exercise training uniquely modulates circulating lipid species beyond classical lipid levels in humans.EBioMedicine · 2025Trial
- Electroacupuncture Reduces Waistline in Patients with Abdominal Obesity: A Randomized Controlled Trial with Mechanistic Analysis of Lipidomic and Intestinal Microbiota.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Trial
- The causality between physical activity and gestational diabetes mellitus: a Mendelian randomization study.Molecular genetics and genomics : MGG · 2026Article
- Effects of combined training on heart rate variability and cardiac function and structure in individuals with grade 1 obesity.Physiological reports · 2026Article
- Exercise-induced metabolic remodeling in type 2 diabetes mellitus: insights from metabolomics.Frontiers in endocrinology · 2026Review
- Metabolic Characteristics of Obese Adolescents with Different Degrees of Weight Loss After Identical Exercise Training Intervention.Metabolites · 2025Article
- Obesity mediates the association between psoriasis and diabetes incidence: a population-based study.Diabetology & metabolic syndrome · 2025Article
- Molecular and pathophysiological intersections between arterial hypertension, pulmonary inflammation and diabetes mellitus.Frontiers in pharmacology · 2025Review
- Moderate-intensity Combined Training Induces Lipidomic Changes in Individuals With Obesity and Type 2 Diabetes.The Journal of clinical endocrinology and metabolism · 2024Article
- Integrative metagenomic and lipidomic analyses reveal alterations in children with obesity and after lifestyle intervention.Frontiers in nutrition · 2024Article
- Male infertility risk and plasma lipidome: a Mendelian randomization study.Frontiers in endocrinology · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
contextAlterations in the lipid metabolism are linked to metabolic disorders such as insulin resistance (IR), obesity and type 2 diabetes (T2D). Regular exercise, particularly combined training (CT), is a well-known nonpharmacological treatment that combines aerobic (AT) and resistance (RT) training benefits. However, it is unclear whether moderate-intensity exercise without dietary intervention induces changes in lipid metabolism to promote a "healthy lipidome."
objectiveThe study aimed to investigate the effect of 16 weeks of CT on plasma and white adipose tissue in both sexes, middle-aged individuals with normal weight, obesity (OB), and T2D using an ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS) untargeted lipidomics approach.
methodsBody composition, maximum oxygen consumption (VO2max), strength, and biochemical markers were evaluated before and after the control/training period and correlated with lipid changes. CT consisted of 8 to 10 RT exercises, followed by 35 minutes of AT (45%-70% VO2max), 3 times a week for 16 weeks.
resultsThe CT significantly reduced the levels of saturated and monounsaturated fatty acid side-chains (SFA/MUFA) in sphingolipids, glycerolipids (GL) and glycerophospholipids (GP) as well as reducing fat mass, circumferences and IR. Increased levels of polyunsaturated fatty acids in GPs and GLs were also observed, along with increased fat-free mass, VO2 max, and strength (all P < .05) after training.
conclusionOur study revealed that 16 weeks of moderate-intensity CT remodeled the lipid metabolism in OB, and T2D individuals, even without dietary intervention, establishing a link between exercise-modulated lipid markers and mechanisms that reduce IR and obesity-related comorbidities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.