Evidence map›Paper›PMID 38487919›Full record

ReviewLab on a chip2024

Next generation microfluidics: fulfilling the promise of lab-on-a-chip technologies.

Umut A Gurkan, David K Wood, Dorn Carranza, Luke H Herbertson, Scott L Diamond, E Du, Suvajyoti Guha, Jorge Di Paola, Patrick C Hines, Ian Papautsky and 7 more

Open access · hybridAbstract readReview
In one paragraph

Review in Lab on a chip, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 73 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. A Vein Attempt? Experimental Models for Arteriovenous Fistula Research.Cardiovascular engineering and technology · 2026
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Bridging the Gap Between Static Histology and Dynamic Organ-on-a-Chip Models.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Review
  11. Review
  12. Lab on an end: Micromanipulation using the acoustohydrodynamic pillar array as an end effector.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 14 institutions in 1 country.

Umut A GurkanCase Western Reserve University, USA. umut@case.edu.ORCID 0000-0002-0331-9960
David K WoodUniversity of Minnesota, USA. dkwood@umn.edu.ORCID 0000-0001-5225-2144
Dorn CarranzaUS Food and Drug Administration, USA.
Luke H HerbertsonUS Food and Drug Administration, USA.ORCID 0000-0003-4097-3272
Scott L DiamondUniversity of Pennsylvania, USA.
E DuFlorida Atlantic University, USA.ORCID 0000-0002-0301-0891
Suvajyoti GuhaUS Food and Drug Administration, USA.ORCID 0000-0002-7622-2721
Jorge Di PaolaWashington University in St. Louis, USA.ORCID 0000-0002-1461-2871
Patrick C HinesWayne State University School of Medicine, USA.ORCID 0000-0002-5431-7017
Ian PapautskyUniversity of Illinois Chicago, USA.ORCID 0000-0002-1396-9625
Sergey S ShevkoplyasUniversity of Houston, USA.ORCID 0000-0002-8203-8365
Nathan J SniadeckiUniversity of Washington, USA.ORCID 0000-0001-6960-4492
Vamsee K PamulaBaebies, Inc., USA.ORCID 0000-0002-2062-8634
Prithu SunddVERSITI Blood Research Institute and Medical College of Wisconsin, USA.
Asif RizwanNational Heart, Lung, and Blood Institute, USA.
Pankaj QasbaNational Heart, Lung, and Blood Institute, USA.
Wilbur A LamEmory University School of Medicine, USA. wilbur.lam@emory.edu.ORCID 0000-0002-0325-7990
United States Food and Drug Administration · USNational Heart Lung and Blood Institute · USBaebies (United States) · USCalifornia University of Pennsylvania · USCase Western Reserve University · USEmory University · USFlorida Atlantic University · USMedical College of Wisconsin · USUniversity of Houston · USUniversity of Illinois Chicago · USUniversity of Minnesota · USUniversity of Washington · USWashington University in St. Louis · USWayne State University · US

Funding

Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
Pulmonary arteriole occlusion by platelet-neutrophil micro-emboli in Acute Chest SyndromeR01HL128297 · NHLBI · VERSITI WISCONSIN, INC. · PI SUNDD, PRITHU · 2015 to 2025
$5.4M
CD39-carrying extracellular vesicles regulate pulmonary thrombosis in Sickle Cell DiseaseR01HL166345 · NHLBI · VERSITI WISCONSIN, INC. · PI Prithu Sundd · 2023 to 2026
$3.1M
NHLBI NIH HHS R01 HL128297NHLBI NIH HHS R01 HL166345NIEHS NIH HHS P30 ES027792
6 · The paper itself

Abstract

Microfluidic lab-on-a-chip technologies enable the analysis and manipulation of small fluid volumes and particles at small scales and the control of fluid flow and transport processes at the microscale, leading to the development of new methods to address a broad range of scientific and medical challenges. Microfluidic and lab-on-a-chip technologies have made a noteworthy impact in basic, preclinical, and clinical research, especially in hematology and vascular biology due to the inherent ability of microfluidics to mimic physiologic flow conditions in blood vessels and capillaries. With the potential to significantly impact translational research and clinical diagnostics, technical issues and incentive mismatches have stymied microfluidics from fulfilling this promise. We describe how accessibility, usability, and manufacturability of microfluidic technologies should be improved and how a shift in mindset and incentives within the field is also needed to address these issues. In this report, we discuss the state of the microfluidic field regarding current limitations and propose future directions and new approaches for the field to advance microfluidic technologies closer to translation and clinical use. While our report focuses on using blood as the prototypical biofluid sample, the proposed ideas and research directions can be extrapolated to other areas of hematology, oncology, biology, and medicine.

Indexed as

Microfluidic Analytical TechniquesMicrofluidicsLab-On-A-Chip DevicesTranslational Research, Biomedical

Identifiers

PMID38487919
PMCPMC10964744
OpenAlexW4392455145

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.