Evidence map›Paper›PMID 38487791›Full record

ArticleFrontiers in chemical engineering2022

Progress in silk and silk fiber-inspired polymeric nanomaterials for drug delivery.

Marisa O Pacheco, Lauren E Eccles, Nickolas A Davies, Jostin Armada, Alaura S Cakley, Isiri P Kadambi, Whitney L Stoppel

Abstract read
In one paragraph

Article in Frontiers in chemical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Silk Fibroin Particle-Laden Sponges as a Multiphase Controlled Release Platform.Regenerative engineering and translational medicine · 2025
    Article
  4. Review
  5. Article
  6. Self-Assembly ofIndustrial & engineering chemistry research · 2025
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marisa O PachecoDepartment of Chemical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL.
Lauren E EcclesDepartment of Chemical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL.
Nickolas A DaviesCollege of Medicine, University of Florida, Gainesville, FL.
Jostin ArmadaDepartment of Chemical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL.
Alaura S CakleyDepartment of Chemical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL.
Isiri P KadambiDepartment of Chemical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL.
Whitney L StoppelDepartment of Chemical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL.

Funding

STUDENTS IN HEALTH PROFESSIONAL SCHOOLST35HL007489 · NHLBI · UNIVERSITY OF FLORIDA · PI Scott A Berceli, Robert Maile · 1985 to 2026
$2.4M
NHLBI NIH HHS T35 HL007489
6 · The paper itself

Abstract

The fields of drug and gene delivery have been revolutionized by the discovery and characterization of polymer-based materials. Polymeric nanomaterials have emerged as a strategy for targeted delivery because of features such as their impressive biocompatibility and improved availability. Use of naturally derived polymers in these nanomaterials is advantageous due to their biodegradability and bioresorption. Natural biopolymer-based particles composed of silk fibroins and other silk fiber-inspired proteins have been the focus of research in drug delivery systems due to their simple synthesis, tunable characteristics, and ability to respond to stimuli. Several silk and silk-inspired polymers contain a high proportion of reactive side groups, allowing for functionalization and addition of targeting moieties. In this review, we discuss the main classes of silk and silk-inspired polymers that are being used in the creation of nanomaterials. We also focus on the fabrication techniques used in generating a tunable design space of silk-based polymeric nanomaterials and detail how that translates into use for drug delivery to several distinct microenvironments.

Indexed as

drug deliverynanomaterialsnatural biopolymerspolymeric nanoparticlessilk

Identifiers

PMID38487791
PMCPMC10939129

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.