ArticleBiological imaging2023
Visualization and quality control tools for large-scale multiplex tissue analysis in TissUUmaps3.
Article in Biological imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Antibody-Based Multiplex Image Analysis: Standard Analytical Workflows and Artificial Intelligence Tools for Pathologists.Laboratory investigation; a journal of technical methods and pathology · 2025Review
- Empowering integrative and collaborative exploration of single-cell and spatial multimodal data with SGS genome browser.Cell genomics · 2025Article
- A perspective on FAIR quality control in multiplexed imaging data processing.Frontiers in bioinformatics · 2024Article
- Voyager: exploratory single-cell genomics data analysis with geospatial statistics.bioRxiv : the preprint server for biology · 2023Article
- Article
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Authors and funding
8 authors.
Funding
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Abstract
Large-scale multiplex tissue analysis aims to understand processes such as development and tumor formation by studying the occurrence and interaction of cells in local environments in, for example, tissue samples from patient cohorts. A typical procedure in the analysis is to delineate individual cells, classify them into cell types, and analyze their spatial relationships. All steps come with a number of challenges, and to address them and identify the bottlenecks of the analysis, it is necessary to include quality control tools in the analysis workflow. This makes it possible to optimize the steps and adjust settings in order to get better and more precise results. Additionally, the development of automated approaches for tissue analysis requires visual verification to reduce skepticism with regard to the accuracy of the results. Quality control tools could be used to build users' trust in automated approaches. In this paper, we present three plugins for visualization and quality control in large-scale multiplex tissue analysis of microscopy images. The first plugin focuses on the quality of cell staining, the second one was made for interactive evaluation and comparison of different cell classification results, and the third one serves for reviewing interactions of different cell types.
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Registered trials
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