Evidence map›Paper›PMID 38487369›Full record

ArticleComputational and structural biotechnology journal2024

Stabilization of the retromer complex: Analysis of novel binding sites of bis-1,3-phenyl guanylhydrazone 2a to the VPS29/VPS35 interface.

Elisa Fagnani, Francesco Bonì, Pierfausto Seneci, Davide Gornati, Luca Muzio, Eloise Mastrangelo, Mario Milani

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and structural biotechnology journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Elisa FagnaniBiophysics Institute, CNR-IBF, Via Corti 12, I-20133 Milano, Italy.
Francesco BonìBiophysics Institute, CNR-IBF, Via Corti 12, I-20133 Milano, Italy.
Pierfausto SeneciDepartment of Chemistry, University of Milan, Via Celoria 26, I-20133 Milano, Italy.
Davide GornatiDepartment of Chemistry, University of Milan, Via Celoria 26, I-20133 Milano, Italy.
Luca MuzioINSPE-Institute of Experimental Neurology, San Raffaele Scientific Institute, Via Olgettina 60, I-20132 Milano, Italy.
Eloise MastrangeloBiophysics Institute, CNR-IBF, Via Corti 12, I-20133 Milano, Italy.
Mario MilaniBiophysics Institute, CNR-IBF, Via Corti 12, I-20133 Milano, Italy.
University of Milan · ITVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The stabilization of the retromer protein complex can be effective in the treatment of different neurological disorders. Following the identification of bis-1,3-phenyl guanylhydrazone

Indexed as

Crystal structureMolecular dynamics simulationsProtein binding sitesProtein ligand interaction

Identifiers

PMID38487369
PMCPMC10937258
OpenAlexW4392345030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.