Evidence map›Paper›PMID 38487343›Full record

ArticleFrontiers in endocrinology2024

Relevance of mutations in protein deubiquitinases genes and

Monika Pękul, Magdalena Szczepaniak, Paulina Kober, Natalia Rusetska, Beata J Mossakowska, Szymon Baluszek, Artur Kowalik, Maria Maksymowicz, Grzegorz Zieliński, Jacek Kunicki and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Grading and staging for pituitary neuroendocrine tumors.Brain pathology (Zurich, Switzerland) · 2025
    Review
  6. Review
  7. Germline Variants in Sporadic Pituitary Adenomas.Journal of the Endocrine Society · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Monika PękulDepartment of Cancer Pathomorphology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
Magdalena SzczepaniakDepartment of Molecular Diagnostics, Holy Cross Cancer Center, Kielce, Poland.
Paulina KoberDepartment of Molecular and Translational Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
Natalia RusetskaDepartment of Experimental Immunology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
Beata J MossakowskaDepartment of Molecular and Translational Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
Szymon BaluszekDepartment of Molecular and Translational Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
Artur KowalikDepartment of Molecular Diagnostics, Holy Cross Cancer Center, Kielce, Poland.
Maria MaksymowiczDepartment of Cancer Pathomorphology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
Grzegorz ZielińskiDepartment of Neurosurgery, Military Institute of Medicine - National Research Institute, Warsaw, Poland.
Jacek KunickiDepartment of Neurosurgery, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
Przemysław WitekDepartment of Internal Medicine, Endocrinology and Diabetes, Medical University of Warsaw, Warsaw, Poland.
Mateusz BujkoDepartment of Molecular and Translational Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
The Maria Sklodowska-Curie National Research Institute of Oncology · PLHoly Cross University · PLJan Kochanowski University · PLMedical University of Warsaw · PLWojskowy Instytut Medycyny Lotniczej · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Corticotroph pituitary neuroendocrine tumors (PitNETs) develop from ACTH-producing cells. They commonly cause Cushing's disease (CD), however, some remain clinically silent. Recurrent Methods: Study included 147 patients (100 CD and 47 silent tumors) that were screened for hot-spot mutations in Results: Conclusions: We confirmed high prevalence of

Indexed as

ACTH-Secreting Pituitary AdenomaAdenomaPituitary ACTH HypersecretionPituitary NeoplasmsCorticotrophsDeubiquitinating EnzymesEndopeptidasesFemaleHumansMutationProto-Oncogene Proteins B-rafTumor Suppressor Protein p53Deubiquitinating EnzymesEndopeptidasesProto-Oncogene Proteins B-rafTP53 protein, humanTumor Suppressor Protein p53BRAFcorticotroph PitNETCushing’s diseasesilent corticotroph tumorTP53USP48USP8

Identifiers

PMID38487343
PMCPMC10937451
OpenAlexW4392292256

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.