ArticleFrontiers in endocrinology2024
Analysis of white matter tract integrity using diffusion kurtosis imaging reveals the correlation of white matter microstructural abnormalities with cognitive impairment in type 2 diabetes mellitus.
Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 7 citations in OpenAlex.
- Diffusion Magnetic Resonance Imaging Models for Detecting Brain Microstructural Abnormalities in Type 2 Diabetes: A Systematic Review.Bioengineering (Basel, Switzerland) · 2026Review
- Neurodegeneration and energy depletion in MS: Links between tissue integrity loss and microvascular changes in white matter disease.Neuroimage. Reports · 2026Article
- Association of composite biomarkers with imaging burden in cerebral small vessel disease.Lipids in health and disease · 2026Article
- Neuroanatomical substrates of perivascular space index: a morphometric and tractography study.Frontiers in psychiatry · 2026Article
- Structural changes in gray matter and white matter across the Alzheimer's disease continuum.Frontiers in neuroscience · 2026Article
- Epicenter mapping of cortical morphological dedifferentiation in type 2 diabetes mellitus using morphometric inverse divergence.Frontiers in aging neuroscience · 2026Article
- Brain Microstructural Alteration and Its Implications for Postoperative Delirium in Elderly Surgical Patients: A Narrative Review.Brain and behavior · 2025Review
- White Matter Microstructural Alterations in Type 2 Diabetes: A Combined UK Biobank Study of Diffusion Tensor Imaging and Neurite Orientation Dispersion and Density Imaging.Medicina (Kaunas, Lithuania) · 2025Article
- Association of diffusion tensor imaging along the perivascular space index with cognitive impairment in type 2 diabetes mellitus.Quantitative imaging in medicine and surgery · 2025Article
- White Matter Function and Network Abnormalities in Patients with Diabetic Retinopathy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Diabetes mellitus exacerbates changes in white matter hyperintensity shapes and volume: A longitudinal study.Alzheimer's & dementia (New York, N. Y.)Article
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
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Abstract
Background: This study aimed to identify disruptions in white matter integrity in type 2 diabetes mellitus (T2DM) patients by utilizing the white matter tract integrity (WMTI) model, which describes compartment-specific diffusivities in the intra- and extra-axonal spaces, and to investigate the relationship between WMTI metrics and clinical and cognitive measurements. Methods: A total of 73 patients with T2DM and 57 healthy controls (HCs) matched for age, sex, and education level were enrolled and underwent diffusional kurtosis imaging and cognitive assessments. Tract-based spatial statistics (TBSS) and atlas-based region of interest (ROI) analysis were performed to compare group differences in diffusional metrics, including fractional anisotropy (FA), mean diffusivity (MD), axonal water fraction (AWF), intra-axonal diffusivity (D Results: In the TBSS analysis, the T2DM group exhibited decreased FA and AWF and increased MD, D Conclusions: WMTI is more sensitive than diffusion tensor imaging in detecting T2DM-related WM microstructure abnormalities and can provide novel insights into the possible pathological changes underlying WM degeneration in T2DM. D
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