Evidence map›Paper›PMID 38487244›Full record

ArticleChemical science2024

Switching the proton-coupled electron transfer mechanism for non-canonical tyrosine residues in a

Astrid Nilsen-Moe, Clorice R Reinhardt, Ping Huang, Hemlata Agarwala, Rosana Lopes, Mauricio Lasagna, Starla Glover, Sharon Hammes-Schiffer, Cecilia Tommos, Leif Hammarström

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. From single step hops to emergent biological phenomena.Journal of inorganic biochemistry · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Hydrogen production by a fullyDalton transactions (Cambridge, England : 2003) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Astrid Nilsen-MoeDepartment of Chemistry, Ångström Laboratory, Uppsala University Box 523 75120 Uppsala Sweden leif.hammarstrom@kemi.uu.se.
Clorice R ReinhardtDepartment of Molecular Biophysics and Biochemistry, Yale University New Haven CT 06520 USA.ORCID https://orcid.org/0000-0002-6083-4950
Ping HuangDepartment of Chemistry, Ångström Laboratory, Uppsala University Box 523 75120 Uppsala Sweden leif.hammarstrom@kemi.uu.se.ORCID https://orcid.org/0000-0002-7676-6905
Hemlata AgarwalaTechnical University Munich, Campus Straubing for Biotechnology and Sustainability Uferstraße 53 94315 Straubing Germany.
Rosana LopesDepartment of Biochemistry and Biophysics, Texas A&M University College Station TX 77843 USA tommos@tamu.edu.ORCID https://orcid.org/0009-0008-0278-1417
Mauricio LasagnaDepartment of Biochemistry and Biophysics, Texas A&M University College Station TX 77843 USA tommos@tamu.edu.ORCID https://orcid.org/0000-0001-5769-7978
Starla GloverDepartment of Chemistry, Ångström Laboratory, Uppsala University Box 523 75120 Uppsala Sweden leif.hammarstrom@kemi.uu.se.
Sharon Hammes-SchifferDepartment of Chemistry, Yale University New Haven CT 06520 USA.ORCID https://orcid.org/0000-0002-3782-6995
Cecilia TommosDepartment of Biochemistry and Biophysics, Texas A&M University College Station TX 77843 USA tommos@tamu.edu.ORCID https://orcid.org/0000-0001-8095-8873
Leif HammarströmDepartment of Chemistry, Ångström Laboratory, Uppsala University Box 523 75120 Uppsala Sweden leif.hammarstrom@kemi.uu.se.ORCID https://orcid.org/0000-0002-9933-9084
Uppsala University · SETexas A&M University · USYale University · US

Funding

Understanding Protein RadicalsR01GM079190 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI TOMMOS, CECILIA · 2008 to 2024
$3.6M
Coupled Protons and Electrons in Biological SystemsR35GM139449 · NIGMS · YALE UNIVERSITY · PI HAMMES-SCHIFFER, SHARON · 2021 to 2025
$2.1M
NIGMS NIH HHS R01 GM079190NIGMS NIH HHS R35 GM139449
6 · The paper itself

Abstract

The proton-coupled electron transfer (PCET) reactions of tyrosine (Y) are instrumental to many redox reactions in nature. This study investigates how the local environment and the thermodynamic properties of Y influence its PCET characteristics. Herein, 2- and 4-mercaptophenol (MP) are placed in the well-folded α

Identifiers

PMID38487244
PMCPMC10935721
OpenAlexW4391232952

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.