Evidence map›Paper›PMID 38487220›Full record

ArticleChemical science2024

Tuning the photoactivated anticancer activity of Pt(iv) compounds

Huayun Shi, Fortuna Ponte, Jaspreet S Grewal, Guy J Clarkson, Cinzia Imberti, Ian Hands-Portman, Robert Dallmann, Emilia Sicilia, Peter J Sadler

Abstract read
In one paragraph

Article in Chemical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Huayun ShiDepartment of Chemistry, University of Warwick Coventry CV4 7AL UK p.j.sadler@warwick.ac.uk.ORCID https://orcid.org/0000-0003-2334-7886
Fortuna PonteDepartment of Chemistry and Chemical Technologies, University of Calabria via Pietro Bucci, 87036 Arcavacata di Rende Cs Italy.ORCID https://orcid.org/0000-0002-4431-9510
Jaspreet S GrewalDivision of Biomedical Sciences, Warwick Medical School CV4 7AL Coventry UK.
Guy J ClarksonDepartment of Chemistry, University of Warwick Coventry CV4 7AL UK p.j.sadler@warwick.ac.uk.ORCID https://orcid.org/0000-0003-3076-3191
Cinzia ImbertiDepartment of Chemistry, University of Warwick Coventry CV4 7AL UK p.j.sadler@warwick.ac.uk.ORCID https://orcid.org/0000-0003-1187-7951
Ian Hands-PortmanSchool of Life Science, University of Warwick Coventry CV4 7AL UK.ORCID https://orcid.org/0000-0002-8895-2342
Robert DallmannDivision of Biomedical Sciences, Warwick Medical School CV4 7AL Coventry UK.ORCID https://orcid.org/0000-0002-7490-0218
Emilia SiciliaDepartment of Chemistry and Chemical Technologies, University of Calabria via Pietro Bucci, 87036 Arcavacata di Rende Cs Italy.ORCID https://orcid.org/0000-0001-5952-9927
Peter J SadlerDepartment of Chemistry, University of Warwick Coventry CV4 7AL UK p.j.sadler@warwick.ac.uk.ORCID https://orcid.org/0000-0001-9160-1941

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photoactive prodrugs offer potential for spatially-selective antitumour activity with minimal effects on normal tissues. Excited-state chemistry can induce novel effects on biochemical pathways and combat resistance to conventional drugs. Photoactive metal complexes in particular, have a rich and relatively unexplored photochemistry, especially an ability to undergo facile intersystem crossing and populate triplet states. We have conjugated the photoactive octahedral Pt(iv) complex

Identifiers

PMID38487220
PMCPMC10935708

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.