Evidence map›Paper›PMID 38487174›Full record

ArticleFrontiers in pharmacology2024

Modification of 4-(4-chlorothiophen-2-yl)thiazol-2-amine derivatives for the treatment of analgesia and inflammation: synthesis and

Mater H Mahnashi, Umer Rashid, Hassan Hussain Almasoudi, Mohammed H Nahari, Imran Ahmad, Abdulkarim S Binshaya, Osama Abdulaziz, Meshari A Alsuwat, Muhammad Saeed Jan, Abdul Sadiq

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Exploring the Therapeutic Potential ofFood science & nutrition · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Exploring Thiophene Derivatives: Synthesis Strategies and Biological Significance.Medicinal chemistry (Shariqah (United Arab Emirates)) · 2025
    Review
  7. Article
  8. Editorial: Recent advances in immunometabolism.Frontiers in pharmacology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Mater H MahnashiDepartment of Pharmaceutical Chemistry, Pharmacy School, Najran University, Najran, Saudi Arabia.
Umer RashidDepartment of Chemistry, COMSATS University Islamabad, Abbottabad, Pakistan.
Hassan Hussain AlmasoudiDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Najran University, Najran, Saudi Arabia.
Mohammed H NahariDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Najran University, Najran, Saudi Arabia.
Imran AhmadFaculty of Pharmacy, Bahauddin Zakaria University, Multan, Pakistan.
Abdulkarim S BinshayaDepartment of Medical Laboratory Sciences, College of Applied medical sciences, Prince Sattam bin Abdulaziz University, Alkharj, Saudi Arabia.
Osama AbdulazizClinical Laboratory Sciences Department, College of Applied Medical Sciences, Taif University, Al-Taif, Saudi Arabia.
Meshari A AlsuwatClinical Laboratory Sciences Department, College of Applied Medical Sciences, Taif University, Al-Taif, Saudi Arabia.
Muhammad Saeed JanDepartment of Pharmacy, Bacha Khan University, Charsadda, Pakistan.
Abdul SadiqDepartment of Pharmacy, Faculty of Biological Sciences, University of Malakand, Chakdara, Pakistan.
Najran University · SATaif University · SABacha Khan University · PKBahauddin Zakariya University · PKCOMSATS University Islamabad · PKPrince Sattam Bin Abdulaziz University · SAUniversity of Malakand · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation is a protective response to a variety of infectious agents. To develop a new anti-inflammatory drug, we explored a pharmacologically important thiazole scaffold in this study. In a multi-step synthetic approach, we synthesized seven new thiazole derivatives (

Indexed as

analgesiccyclooxygenaseinflammationin vivo mechanismLOXthiazole

Identifiers

PMID38487174
PMCPMC10937574
OpenAlexW4392289987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.