Evidence map›Paper›PMID 38487075›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)

Risk factors and cognitive correlates of white matter hyperintensities in ethnically diverse populations without dementia: The COSMIC consortium.

Keshuo Lin, Wei Wen, Darren M Lipnicki, Louise Mewton, Rory Chen, Jing Du, Dadong Wang, Ingmar Skoog, Therese Rydberg Sterner, Jenna Najar and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
  4. Review
  5. Article
  6. ARTS is associated with vascular risk factors, MCI, dementia, and stroke.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 10 institutions in 5 countries.

Keshuo LinCentre for Healthy Brain Ageing School of Clinical Medicine University of New South Wales Sydney New South Wales Australia.ORCID https://orcid.org/0009-0003-6958-5174
Wei WenCentre for Healthy Brain Ageing School of Clinical Medicine University of New South Wales Sydney New South Wales Australia.
Darren M LipnickiCentre for Healthy Brain Ageing School of Clinical Medicine University of New South Wales Sydney New South Wales Australia.
Louise MewtonCentre for Healthy Brain Ageing School of Clinical Medicine University of New South Wales Sydney New South Wales Australia.
Rory ChenCentre for Healthy Brain Ageing School of Clinical Medicine University of New South Wales Sydney New South Wales Australia.
Jing DuCentre for Healthy Brain Ageing School of Clinical Medicine University of New South Wales Sydney New South Wales Australia.
Dadong WangQuantitative Imaging Research Team CSIRO Informatics and Statistics North Ryde New South Wales Australia.
Ingmar SkoogNeuropsychiatric Epidemiology Unit Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology Sahlgrenska Academy University of Gothenburg Gothenburg Sweden.
Therese Rydberg SternerNeuropsychiatric Epidemiology Unit Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology Sahlgrenska Academy University of Gothenburg Gothenburg Sweden.
Jenna NajarNeuropsychiatric Epidemiology Unit Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology Sahlgrenska Academy University of Gothenburg Gothenburg Sweden.
Ki Woong KimDepartment of Neuropsychiatry Seoul National University Bundang Hospital Seongnam South Korea.
Ji Won HanDepartment of Neuropsychiatry Seoul National University Bundang Hospital Seongnam South Korea.
Jun Sung KimDepartment of Neuropsychiatry Seoul National University Bundang Hospital Seongnam South Korea.
Tze Pin NgDepartment of Psychological Medicine Khoo Teck Puat Hospital Yishun Singapore.
Roger HoInstitute for Health Innovation and Technology (iHealthtech) National University of Singapore Singapore Singapore.
Denise Qian Ling ChuaDepartment of Psychological Medicine National University of Singapore Singapore Singapore.
Kaarin J AnsteySchool of Psychology University of New South Wales Sydney New South Wales Australia.
Nicolas CherbuinNational Centre for Epidemiology and Population Health College of Health and Medicine Australian National University Canberra Australian Capital Territory Australia.
Moyra E MortbySchool of Psychology University of New South Wales Sydney New South Wales Australia.
Henry BrodatyCentre for Healthy Brain Ageing School of Clinical Medicine University of New South Wales Sydney New South Wales Australia.
Nicole KochanCentre for Healthy Brain Ageing School of Clinical Medicine University of New South Wales Sydney New South Wales Australia.
Perminder S SachdevCentre for Healthy Brain Ageing School of Clinical Medicine University of New South Wales Sydney New South Wales Australia.
Jiyang JiangCentre for Healthy Brain Ageing School of Clinical Medicine University of New South Wales Sydney New South Wales Australia.ORCID https://orcid.org/0000-0002-2147-6302
Cohort Studies of Memory in an International Consortium (COSMIC)
UNSW Sydney · AUNational University of Singapore · SGSeoul National University · KRAmsterdam University Medical Centers · NLAustralian National University · AUCommonwealth Scientific and Industrial Research Organisation · AUMinistry of Health · SGSahlgrenska University Hospital · SESeoul National University Bundang Hospital · KRStockholm University · SE

Funding

A global epidemiology of cognitive impairment and dementia due to Alzheimer's disease and related disorders: the COSMIC CollaborationR01AG057531 · NIA · UNIVERSITY OF NEW SOUTH WALES · PI Perminder S SACHDEV · 2023 to 2026
$5.9M
COSMIC: An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethno-racial groups and geographical settingsRF1AG057531 · NIA · UNIVERSITY OF NEW SOUTH WALES · PI SACHDEV, PERMINDER S · 2017 to 2020
$2.9M
NIA NIH HHS R01 AG057531NIA NIH HHS RF1 AG057531
6 · The paper itself

Abstract

introductionWhite matter hyperintensities (WMHs) are an important imaging marker for cerebral small vessel diseases, but their risk factors and cognitive associations have not been well documented in populations of different ethnicities and/or from different geographical regions.

methodsWe investigated how WMHs were associated with vascular risk factors and cognition in both Whites and Asians, using data from five population-based cohorts of non-demented older individuals from Australia, Singapore, South Korea, and Sweden (

resultsFactors associated with larger whole brain WMH volumes included diabetes, hypertension, stroke, current smoking, body mass index, higher alcohol intake, and insufficient physical activity. Hypertension and stroke had stronger associations with WMH volumes in Whites than in Asians. No associations between WMH volumes and cognitive performance were found after correction for multiple testing.

conclusionThe current study highlights ethnic differences in the contributions of vascular risk factors to WMHs.

Indexed as

cognitionethnic differencespopulation‐based studiesvascular risk factorswhite matter hyperintensities

Identifiers

PMID38487075
PMCPMC10937819
OpenAlexW4392826468

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.