ReviewFrontiers in medicine2024
Application of dental pulp stem cells for bone regeneration.
Review in Frontiers in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Electrospun Bio-Scaffolds for Mesenchymal Stem Cell-Mediated Neural Differentiation: Systematic Review of Advances and Future Directions.International journal of molecular sciences · 2025Pooled it
- Regenerative potential of human dental pulp stem cells in scaffold-based alveolar and jaw bone reconstruction: a systematic review.BMC oral health · 2025Pooled it
- Comparison of the osteoinductive potential of preconditioned dental pulp stem cell secretome versus their exosomes.Odontology · 2026Article
- SA/HA double-network hydrogel combined with PVDF electret membrane enhances osteogenic differentiation of DPSCs and promotes mandibular bone defect repair.Regenerative therapy · 2026Article
- Flavonoids ofPreventive nutrition and food science · 2026Article
- Exosome-loaded hydrogels for bone regeneration: a cell-free therapeutic strategy.Journal of biological engineering · 2026Review
- Calcium-enriched mesoporous silica/PLGA scaffolds enhance bone repair in a rabbit femoral condylar defect model.Scientific reports · 2026Article
- Dental Pulp Stem Cell-Derived Intracellular Vesicles Promote Cartilage Regeneration and Alleviate Pain in Temporomandibular Joint Osteoarthritis.International dental journal · 2026Article
- Stem cell-based scaffolds using dental pulp and adipose-derived stem cells in periodontal regeneration: Evidence from preclinical or clinical studies.Bioinformation · 2026Article
- Induction of Mesenchymal Stem Cell and Preosteoblast Differentiation: A Comparative Study Between Conditioned Medium and In Vitro Coculture.International journal of dentistry · 2026Article
- Stem cell-derived secretome and dental pulp stem cells enhance sciatic nerve regeneration in a rat sciatic neurotmesis model using chitosan nerve conduits.Frontiers in cell and developmental biology · 2026Article
- A bioactive composite of freeze-dried stem cells, porous microcarriers, and fibrinogen-thrombin gel for dental pulp tissue engineering.American journal of stem cells · 2026Article
- Hurdles to overcome for mesenchymal stem cell translation from bench to bedside.World journal of stem cells · 2025Review
- Functionalized mesenchymal stem cells for enhanced bone regeneration: advances and challenges.Stem cell research & therapy · 2025Review
- Neuronal Differentiation and Exosome Profiling of Dental Pulp Stem Cells: Unveiling Their Potential for Nerve Repair.International journal of molecular sciences · 2025Article
- Cell-Free bone regeneration using dental MSCs secretomes from pulp and gingiva in rabbit tibial defects.Scientific reports · 2025Article
- Application of dental pulp stem cell-conditioned medium combined with deep cryopreservation of autologous cranial flaps.Stem cell research & therapy · 2025Article
- Overexpression of interleukin-4 using adeno-associated virus is a potential strategy to enhance bone regeneration.JBMR plus · 2025Article
- Temporal Profiling of Cellular and Molecular Processes in Osteodifferentiation of Dental Pulp Stem Cells.Biology · 2025Article
- CaFrontiers in cell and developmental biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone defects resulting from severe trauma, tumors, inflammation, and other factors are increasingly prevalent. Stem cell-based therapies have emerged as a promising alternative. Dental pulp stem cells (DPSCs), sourced from dental pulp, have garnered significant attention owing to their ready accessibility and minimal collection-associated risks. Ongoing investigations into DPSCs have revealed their potential to undergo osteogenic differentiation and their capacity to secrete a diverse array of ontogenetic components, such as extracellular vesicles and cell lysates. This comprehensive review article aims to provide an in-depth analysis of DPSCs and their secretory components, emphasizing extraction techniques and utilization while elucidating the intricate mechanisms governing bone regeneration. Furthermore, we explore the merits and demerits of cell and cell-free therapeutic modalities, as well as discuss the potential prospects, opportunities, and inherent challenges associated with DPSC therapy and cell-free therapies in the context of bone regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.