Evidence map›Paper›PMID 38486781›Full record

ArticleHeliyon2024

Diagnostic performance of plasma D-dimer, fibrinogen, and D-dimer to fibrinogen ratio as potential biomarkers to predict hypertension-associated acute ischemic stroke.

Endeshaw Chekol Abebe, Tadesse Asmamaw Dejenie, Denekew Tenaw Anley, Misganaw Asmamaw Mengstie, Natnael Atnafu Gebeyehu, Getachew Asmare Adella, Gizachew Ambaw Kassie, Natnael Amare Tesfa, Molalegn Mesele Gesese, Sefineh Fenta Feleke and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 4 institutions in 2 countries.

Endeshaw Chekol AbebeDepartment of Biochemistry, College of Health Science, Debre Tabor University, Debre Tabor, Ethiopia.
Tadesse Asmamaw DejenieDepartment of Medical Biochemistry, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Denekew Tenaw AnleyDepartment of Public Health, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Misganaw Asmamaw MengstieDepartment of Biochemistry, College of Health Science, Debre Tabor University, Debre Tabor, Ethiopia.
Natnael Atnafu GebeyehuDepartment of Midwifery, College of Medicine and Health Science, Wolaita Sodo University, Sodo, Ethiopia.
Getachew Asmare AdellaDepartment of Reproductive Health and Nutrition, School of Public Health, Woliata Sodo University, Sodo, Ethiopia.
Gizachew Ambaw KassieDepartment of Epidemiology and Biostatistics, School of Public Health, Woliata Sodo University, Sodo, Ethiopia.
Natnael Amare TesfaSchool of Medicine, College of Health Science, Woldia University, Woldia, Ethiopia.
Molalegn Mesele GeseseDepartment of Midwifery, College of Medicine and Health Science, Wolaita Sodo University, Sodo, Ethiopia.
Sefineh Fenta FelekeDepartment of Public Health, College of Health Sciences, Woldia University, Woldia, Ethiopia.
Melkamu Aderajew ZemeneDepartment of Public Health, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Anteneh Mengist DessieDepartment of Public Health, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Wubet Alebachew BayihDepartment of Maternal and Neonatal Health Nursing, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Yenealem Solomon KebedeDepartment of Medical Laboratory Science, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Berihun BantieDepartment of Comprehensive Nursing, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Mohammed Abdu SeidDepartment of Physiology, College of Health Science, Debre Tabor University, Debre Tabor, Ethiopia.
Engidaw Fentahun EnyewDepartment of Anatomy, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Gashaw DessieDepartment of Medical Biochemistry, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Dagnew Getnet AdugnaDepartment of Anatomy, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Teklie Mengie AyeleDepartment of Pharmacy, College of Health Science, Debre Tabor University, Debre Tabor, Ethiopia.
Assefa Agegnehu TeshomeDepartment of Anatomy, College of Health Science, Debre Tabor University, Debre Tabor, Ethiopia.
Fitalew Tadele AdmasuDepartment of Biochemistry, College of Health Science, Debre Tabor University, Debre Tabor, Ethiopia.
Debre Tabor University · ETUniversity of Gondar · ETWolaita Sodo University · ETWoldia University · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ischemic stroke is a common type of stroke that leads to death and functional disability in hypertensive patients. However, there are no well-studied non-invasive and less expensive fluid biomarkers routinely used to detect ischemic stroke in hypertensive patients. Hence, this study aimed to tease out the performance of D-dimer, fibrinogen, and the D-dimer to fibrinogen ratio (DDFR) in predicting hypertension-associated acute ischemic stroke. Methods: A hospital-based cross-sectional study was done from October 2022 to January 2022 at Yikatit 12 Hospital Medical College, Ethiopia. We recruited 55 hypertensive patients who had an ischemic stroke and 110 who did not. A ROC curve was used to calculate the areas under the curves (AUCs) and determine the diagnostic power of the D-dimer, fibrinogen, and DDFR. The Youden index was used to find the best cut-off points for biomarkers in detecting acute ischemic stroke. A De Long test was employed to show whether there was a significant difference between the AUCs of biomarkers in diagnosing ischemic stroke. Results: D-dimer yielded the highest diagnostic power (AUC = 0.776) in detecting acute ischemic stroke, followed by DDFR (AUC = 0.763) and fibrinogen (AUC = 0.694), but there was no significant difference between them. At 0.52 μg/ml cut-off point, D-dimer had 82.9% sensitivity, 66.7% specificity, 62.5% PPV, and 85.3% NPV to diagnose acute ischemic stroke. Fibrinogen could detect acute ischemic stroke at 405.85 mg/dl level, with 70.0% sensitivity, 57.1% specificity, 41.2% PPV and 81.6% NPV. At a 1.83 ratio, DDFR might also identify ischemic stroke with 80.0% sensitivity, 67.1% specificity, 51.1% PPV, and 88.7% NPV. Conclusion: We showed D-dimer, fibrinogen, and DDFR as promising, affordable, and non-invasive biomarkers for the detection of ischemic stroke among subjects with hypertension. This will help clinicians make an early diagnosis and better guide patient therapy.

Indexed as

Acute ischemic strokeDDFRD-dimerFibrinogenHypertension

Identifiers

PMID38486781
PMCPMC10937710
OpenAlexW4392301464

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.