ArticleFrontiers in rehabilitation sciences2024
Symptom reduction in mal de débarquement syndrome with attenuation of the velocity storage contribution in the central vestibular pathways.
Article in Frontiers in rehabilitation sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 9 citations in OpenAlex.
- Virtual reality application matches the most established treatment for Mal de Debarquement Syndrome: A non-inferiority, randomized, open clinical trial.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Trial
- A Sensory Adaptation Program for Individuals With Mal de Débarquement Syndrome: A Case Series.Journal of neurologic physical therapy : JNPT · 2026Article
- Motorist's Disorientation Syndrome-A Narrative Review.Journal of functional morphology and kinesiology · 2026Review
- Galvanic vestibular stimulation for Mal de Debarquement syndrome: a pilot study on therapeutic potential.Experimental brain research · 2025Article
- Analysis, Design, and Implementation of a User-Friendly Differential Privacy Application.Sensors (Basel, Switzerland) · 2025Article
- Vestibular Agnosia: Toward a Better Understanding of Its Mechanisms.Audiology research · 2025Review
- Potential lesson from a model-based exploration on treatment effect heterogeneity of mal de débarquement syndrome.Frontiers in neurology · 2025Article
- The utility of artificial vestibular stimulation in decoding the pathophysiology of mal de débarquement syndrome.Frontiers in neurology · 2025Article
- Riding the hilltop: practical implementation and assessment of an implicit hilltop illusion.Frontiers in neurology · 2025Article
- On labyrinthine function loss, motion sickness immunity, and velocity storage.Frontiers in neurology · 2024Article
- Toward personalized medicine for mal de débarquement syndrome.Frontiers in neurologyArticle
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Background: The velocity storage mechanism of the central vestibular system is closely associated with the vestibulo-ocular reflex (VOR), but also contributes to the sense of orientation in space and the perception of self-motion. We postulate that mal de débarquement syndrome (MdDS) is a consequence of inappropriate sensory adaptation of velocity storage. The premise that a maladapted velocity storage may be corrected by spatial readaptation of the VOR has recently been translated into the development of the first effective treatment for MdDS. However, this treatment's initial impact may be reversed by subsequent re-triggering events. Presently, we hypothesized that MdDS symptoms could alternatively be reduced by attenuating the velocity storage contribution in the central vestibular pathways. Methods: Forty-three patients with MdDS (aged 47 ± 14 yo; 36 women) were randomly assigned to two treatment groups and followed for 6 months. The horizontal VOR was tested with chair rotation during laboratory visits, and the strength of velocity storage was quantified with model-based parameters-the time constant (Tc) and the gain of coupling from the vestibular primary afferent signals (g Results: In Group 1, velocity storage was modified through reduction of g Conclusion: Attenuation of velocity storage shows promise as a lasting remedy for MdDS that can complement the VOR readaptation approach.
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