Evidence map›Paper›PMID 38486384›Full record

ArticleCurrent drug research reviews2025

Bioactive Fractions Isolated from

Jacqueline Njikam, Apeksha Joshi, Emmanuel M Njoya, Kapil Upadhyay, Corinne R Ngnameko, Lyndy J McGaw, Ranjitsinh V Devkar, Frederic N Njayou, Paul F Moundipa

Abstract read
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Article in Current drug research reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Jacqueline NjikamLaboratory of Pharmacology and Toxicology, Department of Biochemistry, Faculty of Science, University of Yaoundé I, PO. Box 812 Yaoundé, Cameroon.
Apeksha JoshiDivision of Phytotherapeutics and Metabolic Endocrinology, Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, 390002, India.
Emmanuel M NjoyaLaboratory of Pharmacology and Toxicology, Department of Biochemistry, Faculty of Science, University of Yaoundé I, PO. Box 812 Yaoundé, Cameroon.
Kapil UpadhyayDivision of Phytotherapeutics and Metabolic Endocrinology, Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, 390002, India.
Corinne R NgnamekoDepartment of Pharmacology, Faculty of Health Sciences, University of the Free State, Bloemfontein, 9300, Free State, Republic of South Africa.
Lyndy J McGawPhytomedicine Program, Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort, Pretoria, 0110, South Africa.
Ranjitsinh V DevkarDivision of Phytotherapeutics and Metabolic Endocrinology, Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, 390002, India.
Frederic N NjayouLaboratory of Pharmacology and Toxicology, Department of Biochemistry, Faculty of Science, University of Yaoundé I, PO. Box 812 Yaoundé, Cameroon.
Paul F MoundipaLaboratory of Pharmacology and Toxicology, Department of Biochemistry, Faculty of Science, University of Yaoundé I, PO. Box 812 Yaoundé, Cameroon.
Maharaja Sayajirao University of Baroda · INUniversité de Yaoundé I · CMCentral University of Technology · ZAInstitut de Recherches Médicales et d’Etudes des Plantes Médicinales · CMUniversity of Pretoria · ZA

Funding

Maharaja Sayajirao University of Baroda, India DST/INT/CVRF/2016
6 · The paper itself

Abstract

background

aimsThis investigation aimed to identify major compounds in bioactive fractions using bioassay- guided fractionation.

methodsThe anti-inflammatory effect of fractions was determined by measuring their inhibitory activity on 15-lipoxygenase and nitric oxide (NO) in lipopolysaccharide-stimulated RAW 264.7 macrophage cells. Additionally, the anti-aging efficacy of the fractions was determined by assessing the expression of markers for the aging process, i.e., expression of tyrosinase (

resultsHexane fraction of HM significantly inhibited (p < 0.05) the 15-lipoxygenase (IC

conclusionOverall, the hexane fraction of HM and methanol fraction of PA displayed effective anti-aging activities, with additional anti-inflammatory effects.

Indexed as

Anti-Inflammatory AgentsCollagenMelaninsPlant ExtractsAnimalsGene Expression RegulationHumansMiceNitric OxideRAW 264.7 CellsSkin AgingUltraviolet RaysAnti-Inflammatory AgentsCollagenMelaninsNitric OxidePlant Extracts<i>Harungana madagascariensisinflammationphotoagingPhytochemicalspigmentationPsorospermum aurantiacum</i>.

Identifiers

PMID38486384
OpenAlexW4394760557

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.