ArticleBMC pregnancy and childbirth2024
The relationship between duration of infertility and clinical outcomes of intrauterine insemination for younger women: a retrospective clinical study.
Article in BMC pregnancy and childbirth, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Exploring Co-Occurring Clinical and Treatment Characteristics Associated with In Vitro Fertilization Failure in Polycystic Ovary Syndrome: An Association Rule Mining Approach.Healthcare (Basel, Switzerland) · 2026Article
- Observational
- A hybrid model to study the demographic profile of women in view of assisted reproductive techniques through machine learning models.Frontiers in reproductive health · 2026Article
- The impact of season, temperature, and direct normal irradiance on IVF pregnancy outcomes: a retrospective cohort study.International journal of biometeorology · 2025Article
- An Artificial Intelligence-Based Model to Predict Pregnancy After Intrauterine Insemination: A Retrospective Analysis of 9501 Cycles.Journal of personalized medicine · 2025Article
- Article
- Journey of infertile couples: scoping the barriers for infertility care among infertile women in Morocco.Obstetrics & gynecology science · 2025Article
- Psychological predictors, moderators, and mediators of treatment outcome among ART-treated women: a prospective study.Frontiers in reproductive health · 2025Article
- The association between female age and pregnancy outcomes in patients receiving first elective single embryo transfer cycle: a retrospective cohort study.Scientific reports · 2024Article
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8 authors.
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Abstract
backgroundThe objective of this research was to elucidate the association between the length of infertility and the outcomes of intrauterine insemination (IUI) in women of varying ages - a topic that has been the subject of investigation for numerous years, yet lacks a definitive consensus.
methodsA retrospective cohort investigation involving 5268 IUI cycles was undertaken at the Reproductive Medicine Center of Nanjing Drum Tower Hospital from 2016 to 2022. Utilizing the smooth fitting curve along with threshold and saturation effect analysis, the correlation between infertility duration and IUI clinical pregnancy rates was discerned. Moreover, patients were bifurcated into two cohorts based on their respective infertility durations. A secondary examination was also performed employing propensity-score matching to mitigate the impact of confounding variables. Subsequent threshold and saturation effect analysis was carried out across various subgroups, segmented on the basis of age differentiation.
resultsWhen the duration of infertility was more than 5 years, the clinical pregnancy rate decreased with the increase of infertility duration (aOR: 0.894, 95%CI: 0.817-0.991, p = 0.043). The multivariate regression analysis suggested that longer duration of infertility (≥ 5 years) was significantly correlated with the lower clinical pregnancy rate (aOR: 0.782, 95% CI: 0.643-0.950, p = 0.01). After the propensity-score matching, the clinical pregnancy rate of women with longer infertility duration were also higher. When the duration of infertility was more than 5 years, the clinical pregnancy rate of women younger than 35 years old decreased with the increase of infertility duration (aOR: 0.906, 95%CI: 0.800-0.998, p = 0.043).
conclusionsThe clinical pregnancy rate and live birth rate of IUI in young women (< 35 years old) who have been infertile for more than 5 years significantly decrease with the prolongation of infertility time. Therefore, for young women who have been infertile for more than 5 years, IUI may not be the best choice.
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