Evidence map›Paper›PMID 38486098›Full record

ArticleScientific reports2024

Altered gut microbiota in Taiwanese A97S predominant transthyretin amyloidosis with polyneuropathy.

Chieh-Chang Chen, Ping-Huei Tseng, Hsueh-Wen Hsueh, Ming-Chang Chiang, Shiou-Ru Tzeng, Tsung Hsien Chiang, Ming-Shiang Wu, Sung-Tsang Hsieh, Chi-Chao Chao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Chieh-Chang Chen *Departments of Gastroenterology, National Taiwan University Hospital, Taipei, Taiwan.
Ping-Huei Tseng *Departments of Gastroenterology, National Taiwan University Hospital, Taipei, Taiwan.
Hsueh-Wen HsuehDepartments of Neurology, National Taiwan University Hospital, Taipei, Taiwan.
Ming-Chang ChiangDepartment of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Shiou-Ru TzengInstitute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Tsung Hsien ChiangDepartments of Gastroenterology, National Taiwan University Hospital, Taipei, Taiwan.
Ming-Shiang WuDepartments of Gastroenterology, National Taiwan University Hospital, Taipei, Taiwan.
Sung-Tsang HsiehDepartments of Neurology, National Taiwan University Hospital, Taipei, Taiwan. shsieh@ntu.edu.tw.
Chi-Chao ChaoDepartments of Neurology, National Taiwan University Hospital, Taipei, Taiwan. chichaochao@ntu.edu.tw.
National Taiwan University Hospital · TWNational Taiwan University · TWNational Yang Ming Chiao Tung University · TW

Funding

Ministry of Science and Technology, Taiwan 109-2320-B-002-024-Ministry of Science and Technology, Taiwan 110-2320-B-002 -072Ministry of Science and Technology, Taiwan 110-2320-B-002-075-Ministry of Science and Technology, Taiwan 111-2320-B-002-078Ministry of Science and Technology, Taiwan T107-2314-B-002-072-MY2National Taiwan University Hospital UN109-004
6 · The paper itself

Abstract

Increasing evidence suggests that gut microbiota alterations are related to development and phenotypes of many neuropsychiatric diseases. Here, we evaluated the fecal microbiota and its clinical correlates in patients with hereditary transthyretin amyloidosis (ATTRv) and polyneuropathy. Fecal microbiota from 38 ATTRv patients and 39 age-matched controls was analyzed by sequencing 16S V3-V4 ribosomal RNA, and its relationships with clinical characteristics of polyneuropathy and cardiomyopathy were explored. The familial amyloidotic polyneuropathy stage was stage I, II, and III in 13, 18, and 7 patients.

Indexed as

Amyloid Neuropathies, FamilialCardiomyopathiesGastrointestinal MicrobiomePolyneuropathiesBacillotaHumansPrealbuminRNA, Ribosomal, 16SPrealbuminRNA, Ribosomal, 16STTR protein, human

Identifiers

PMID38486098
PMCPMC10940600
OpenAlexW4392806731

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.