Trial reportNature medicine2024
Self-help mobile messaging intervention for depression among older adults in resource-limited settings: a randomized controlled trial.
Trial report in Nature medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07161674 (WhatsApp Intervention for Seniors' Digital and Cognitive Management), which is not on this map. Cited by 14 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
WhatsApp Intervention for Seniors' Digital and Cognitive Management (WISDOM): a Mixed-methods Pilot Study
Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A meta-analysis of preventive psychosocial interventions against depressive and anxiety symptoms in older adults.Psychological medicine · 2026Pooled it
- Magnitude of the Digital Placebo Effect and Its Moderators on Generalized Anxiety Symptoms: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2025Pooled it
- Effectiveness of Digital Behavioral Activation Interventions for Depression and Anxiety: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2025Pooled it
- Technology-Enhanced Peer Support for Depression in Older Adults: Single-Arm Mixed Methods Feasibility Study.JMIR formative research · 2026Article
- Engagement and Outcomes Associated With Message-Based Psychotherapy Among Older and Younger Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Article
- Development and validation and risk factor analysis of the colorectal cancer psychosocial distress scale.Scientific reports · 2026Article
- Assessing potential added benefits of trauma-focused content to a guided low-intensity psychoeducational intervention for perinatal women: A propensity score-matched analysis of a nonrandomized trial.Global mental health (Cambridge, England) · 2026Article
- From Passive to Active-Improving the Healthy Self-Help Behavior of Older Adults Through Community Health Association: Mixed Methods Study.Journal of medical Internet research · 2025Article
- Engagement with digital platforms and perspectives on WhatsApp based mental health self-help solution for older adults: a qualitative study from India.Discover mental health · 2025Article
- Digital interventions for common mental health problems among older adults in low- and middle-income countries: a scoping review.BMJ global health · 2025Article
- Article
- Article
- A self-help mobile messaging intervention to improve subthreshold depressive symptoms among older adults in a socioeconomically deprived region of Brazil (PRODIGITAL): a pragmatic, two-arm randomised controlled trial.Lancet regional health. Americas · 2024Article
- Digital mental health interventions: an opportunity to enhance care while preserving human connection.Lancet regional health. Americas · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
Scalable solutions to treat depression in older adults in low-resourced settings are urgently needed. The PRODIGITAL-D pragmatic, single-blind, two-arm, individually randomized controlled trial assessed the effectiveness of a mobile messaging psychosocial intervention in improving depressive symptomatology among older adults in socioeconomically deprived areas of Guarulhos, Brazil. Older adults (aged 60+ years) registered with 24 primary care clinics and identified with depressive symptomatology (9-item Patient Health Questionnaire (PHQ-9) scores ≥ 10) received the 6-week Viva Vida intervention based on psychoeducation and behavioral activation (n = 298) or a single message (n = 305). No health professional support was offered. The primary outcome was improvement from depressive symptomatology (PHQ-9 < 10) at 3 months. Of the 603 participants enrolled (mean age = 65.1 years; 451 (74.8%) women), 527 (87.4%) completed the follow-up assessment. In the intervention arm, 109 of 257 (42.4%) participants had an improved depressive symptomatology, compared with 87 of 270 (32.2%) participants in the control arm (adjusted odds ratio = 1.57; 95% confidence interval = 1.07-2.29; P = 0.019). No severe adverse events related to trial participation were observed. These results demonstrate the usefulness of a digital messaging psychosocial intervention in the short-term improvement from depressive symptomatology that can potentially be integrated into primary care programs for treating older adults with depression. Brazilian Registry of Clinical Trials registration: ReBEC ( RBR-4c94dtn ).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.