ArticleScientific reports2024
Inverted U-shaped relationship between sleep duration and phenotypic age in US adults: a population-based study.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 3 of them syntheses that pooled it.
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The trial behind it
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Who cites it
73 citing papers in PubMed, 3 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- Pooled it
- Prevalence of and risk factors for low back pain among professional drivers: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2024Pooled it
- Impact of exercise type, duration, and intensity on depressive symptoms in older adults: a systematic review and meta-analysis.Frontiers in psychology · 2024Pooled it
- Associations between domain-specific physical activity, sedentary behavior, and binge drinking among adults in the United States and China: evidence from a cross-sectional study, daily tracking, and randomized controlled trial.Frontiers in public health · 2025Trial
- Review
- Optimal 24-Hour Sleep Duration and Depression Risk in Chinese Middle-Aged and Elderly: A Machine Learning and RCS Analysis of Nonlinear Associations.The Psychiatric quarterly · 2026Article
- Exploring the role of β2-microglobulin in the relationship between physical activity and DNAm-predicted PhenoAge: Evidence from a population-based and mice single-cell RNA-sequencing study.Journal of advanced research · 2026Article
- The mediating role of sleep quality in the association between job stress and quality of life among medical university employees.Scientific reports · 2026Article
- Article
- Divergent impacts of estradiol/testosterone reduction on biological aging: optimal HRT window in females recommended.Biology of sex differences · 2026Article
- Distinct roles of chronotype, daytime napping, and sleep duration in biological and functional aging: a univariable and multivariable Mendelian randomization study.Clinical epigenetics · 2026Article
- The impact of triglyceride-glucose-related obesity indices and sleep patterns on accelerated aging: evidence from NHANES 2005-2018.Hormones (Athens, Greece) · 2026Article
- Association between social activities and cardiovascular diseases: evidence from the CHARLS database.BMC public health · 2026Article
- Nonlinear association between sleep duration and thyroid hormone levels in patients with thyroid cancer.Scientific reports · 2026Article
- Relationships between physical activity dimensions and frailty incidence and progression in middle-aged and older adults: A 7-year cohort study.Journal of exercise science and fitness · 2026Article
- The Sleep Connection: Exploring the Role of Composite Dietary Antioxidant Index in Sleep Quality Based on NHANES 2007-2014.International journal of medical sciences · 2026Article
- How Long Should We Sleep? Exploring the Relationship Between Sleep Duration and the Prevalence of Depression.International journal of behavioral medicine · 2025Article
- War, amputation, and resilience: assessing health-related quality of life in Syrian prosthetic users.International journal for equity in health · 2025Article
- Article
- Bidirectional associations between sleep and physical activity investigated using large-scale objective monitoring data.Communications medicine · 2025Article
13 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep is a modifiable behavior that can be targeted in interventions aimed at promoting healthy aging. This study aims to (i) identify the sleep duration trend in US adults; (ii) investigate the relationship between sleep duration and phenotypic age; and (iii) explore the role of exercise in this relationship. Phenotypic age as a novel index was calculated according to biomarkers collected from US adults based on the National Health and Nutrition Examination Survey (NHANES). Sleep information was self-reported by participants and discerned through individual interviews. The principal analytical method employed was weighted multivariable linear regression modeling, which accommodated for the complex multi-stage sampling design. The potential non-linear relationship was explored using a restricted cubic spline (RCS) model. Furthermore, subgroup analyses evaluated the potential effects of sociodemographic and lifestyle factors on the primary study outcomes. A total of 13,569 participants were finally included in, thereby resulting in a weighted population of 78,880,615. An examination of the temporal trends in sleep duration revealed a declining proportion of individuals with insufficient and markedly deficient sleep time since the 2015-2016 cycle. Taken normal sleep group as a reference, participants with extreme short sleep [β (95% CI) 0.582 (0.018, 1.146), p = 0.044] and long sleep [β (95% CI) 0.694 (0.186, 1.203), p = 0.010] were both positively associated with phenotypic age using the fully adjusted model. According to the dose-response relationship between sleep duration and phenotypic age, long sleep duration can benefit from regular exercise activity, whereas short sleep duration with more exercise tended to have higher phenotypic age. There is an inverted U-shaped relationship between short and long sleep durations and phenotypic age. This study represents an important step forward in our understanding of the complex relationship between sleep and healthy aging. By shedding light on this topic and providing practical exercise recommendations for promoting healthy sleep habits, researchers can help individuals live longer, healthier, and more fulfilling lives.
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