ArticleScientific reports2024
Conventional extraction of fucoidan from Irish brown seaweed Fucus vesiculosus followed by ultrasound-assisted depolymerization.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 29 citations in OpenAlex.
- Application of Seaweed-Derived Polysaccharides in Biocrust Technology: Ultrasound-Assisted Fucoidan Extraction from Laminaria digitata.Marine biotechnology (New York, N.Y.) · 2026Article
- Navigating the challenges in fucoidan industrialization: factors affecting biological activity and strategies for application of functional material.Food science and biotechnology · 2026Review
- Advances in ultrasound-enhanced recovery of marine algal polysaccharides: toward sustainable bioprocessing.Ultrasonics sonochemistry · 2025Review
- Convective Drying of Brown Seaweed (Foods (Basel, Switzerland) · 2025Article
- Marine-Origin Polysaccharides and Their Chemically Modified Derivatives as Sources of Advanced Biofunctional Materials for Biomedical Applications.Biomacromolecules · 2025Review
- Antimicrobial, antidiabetic, antiviral, and antioxidant activities of fucoidan extracted from the brown seaweed Padina pavonica.BMC biotechnology · 2025Article
- Ultrasound-assisted HFrontiers in pharmacology · 2025Article
- Polysaccharide-Based Drug Carriers-A Patent Analysis.Gels (Basel, Switzerland) · 2024Review
- Article
- Ultrasound-Assisted Extraction of Alginate fromMarine drugs · 2024Article
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
Fucoidan has attracted considerable attention from scientists and pharmaceutical companies due to its antioxidant, anticoagulant, anti-inflammatory, anti-tumor, and health-enhancing properties. However, the extraction of fucoidan from seaweeds often involves the use of harsh chemicals, which necessitates the search for alternative solvents. Additionally, the high viscosity and low cell permeability of high molecular weight (Mw) fucoidan can limit its effectiveness in drug action, while lower Mw fractions exhibit increased biological activity and are also utilized as dietary supplements. The study aimed to (1) extract fucoidan from the seaweed Fucus vesiculosus (FV) using an environmentally friendly solvent and compare it with the most commonly used extraction solvent, hydrochloric acid, and (2) assess the impact of ultrasound-assisted depolymerization on reducing the molecular weight of the fucoidan extracts and examine the cytotoxic effect of different molecular weight fractions. The findings indicated that the green depolymerization solvent, in conjunction with a brief ultrasound treatment, effectively reduced the molecular weight. Moreover, a significant decrease in cell viability was observed in selected samples, indicating potential anticancer properties. As a result, ultrasound was determined to be an effective method for depolymerizing crude fucoidan from Fucus Vesiculosus seaweed.
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