Evidence map›Paper›PMID 38485607›Full record

ArticleTrends in genetics : TIG2024

Architecture of an RNA polymerase ribozyme illuminates the RNA World.

David M Shechner

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Trends in genetics : TIG, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

David M ShechnerDepartment of Pharmacology, University of Washington, Seattle, WA, USA; Institute for Stem Cell and Regenerative Medicine, Seattle, WA, USA; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA. Electronic address: shechner@uw.edu.
California Institute for Regenerative Medicine · US

Funding

Function, composition, and mechanism of RNA splicing factories in cardiomyopathyR01HL160825 · NHLBI · UNIVERSITY OF WASHINGTON · PI Charles E Murry · 2023 to 2026
$2.3M
Oligonucleotide-directed in situ proximity biotinylation: a unified method for mapping RNA-interacting proteomes, transcriptomes and genomic loci within intact cells.R01GM138799 · NIGMS · UNIVERSITY OF WASHINGTON · PI SHECHNER, DAVID MICHAEL · 2020 to 2024
$1.7M
NHLBI NIH HHS R01 HL160825NIGMS NIH HHS R01 GM138799
6 · The paper itself

Abstract

'Ribo-organisms' of the primordial RNA World would have needed ribozymes that catalyze RNA replication. McRae, Wan, Kristoffersen et al. recently revealed how these RNA replicases might have functioned by solving the structure of an artificial polymerase ribozyme. This work illustrates how complex RNA structures evolve, with implications for the origins of life.

Indexed as

RNARNA, CatalyticDNA-Directed RNA PolymerasesNucleic Acid ConformationDNA-Directed RNA PolymerasesRNARNA, Catalytic

Identifiers

PMID38485607
PMCPMC11003837
OpenAlexW4392768689

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.