Evidence map›Paper›PMID 38485579›Full record

ArticleTrends in parasitology2024

Itaconate as a potential target for antimalarial therapy.

Jonathon P Bernardi, Taylen J Nappi, Noah S Butler

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Trends in parasitology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jonathon P BernardiDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA.
Taylen J NappiInterdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA, USA.
Noah S ButlerDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA; Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA, USA. Electronic address: noah-butler@uiowa.edu.
University of Iowa · US

Funding

TRAINING IN MECHANISMS OF PARASITISMT32AI007511 · NIAID · UNIVERSITY OF IOWA · PI BUTLER, NOAH SULLIVAN, WEBER, MARY · 1996 to 2025
$8.1M
Regulation of Plasmodium-specific CD4+ T CellsR01AI127481 · NIAID · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Noah Sullivan Butler · 2016 to 2026
$3.8M
Development and function of CD4+ memory T cells during malariaR01AI125446 · NIAID · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Noah Sullivan Butler · 2016 to 2026
$3.7M
Mechanisms and consequences of extrafollicular B cell activation during malariaR01AI167058 · NIAID · UNIVERSITY OF IOWA · PI BUTLER, NOAH SULLIVAN · 2021 to 2025
$3.2M
BLRD VA I01 BX000536BLRD VA I01 BX001983NIAID NIH HHS R01 AI125446NIAID NIH HHS R01 AI127481NIAID NIH HHS R01 AI167058NIAID NIH HHS T32 AI007511
6 · The paper itself

Abstract

In a recent publication, Ramalho et al. investigated monocyte-derived dendritic cell (MODC) mobilization in response to Plasmodium infection. The authors showed that elevated levels of itaconate in MODCs results in reduced CD8 T cell activation and that the absence of itaconate is associated with enhanced parasite control.

Indexed as

AntimalarialsSuccinatesCD8-Positive T-LymphocytesDendritic CellsMonocytesAntimalarialsitaconic acidSuccinatesitaconatemalariametabolismmitochondriamonocyte-derived dendritic cellsPD-L1

Identifiers

PMID38485579
PMCPMC10994723
OpenAlexW4392744181

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.