Evidence map›Paper›PMID 38485271›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2024

Interrogating the Theranostic Capacity of a MUC16-Targeted Antibody for Ovarian Cancer.

Kyeara N Mack, Zachary V Samuels, Lukas M Carter, Tara D Viray, Komal Mandleywala, Cory L Brooks, Michael A Hollingsworth, Prakash Radhakrishnan, Jason S Lewis

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Exploring the 89Zr/177Lu Theranostic Pairing with an Extracellular Matrix-Targeted Radiopharmaceutical against Triple-Negative Breast Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Article
  4. Article
  5. Personalizing CA125 Levels Using Tumor Marker Variants: A Case-Control Analysis of Diagnostic Performance for Pancreatic Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
    Article
  6. The molecular blueprint of targeted radionuclide therapy.Nature reviews. Clinical oncology · 2025
    Review
  7. Review
  8. Mucin-Targeted Antibodies for Ovarian Cancer.Seminars in nuclear medicine · 2025
    Review
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Kyeara N MackDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Zachary V SamuelsDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Lukas M CarterDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Tara D VirayDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Komal MandleywalaDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Cory L BrooksDepartment of Chemistry and Biochemistry, California State University, Fresno, California.
Michael A HollingsworthEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska; and.
Prakash RadhakrishnanEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska; and.
Jason S LewisDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York; lewisj2@mskcc.org.
Memorial Sloan Kettering Cancer Center · USCornell University · USUniversity of Nebraska Medical Center · USCalifornia State University, Fresno · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Leveraging Pb-203/212 for the Theranostic Imaging and Therapy of Prostate CancerR35CA232130 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S. · 2019 to 2025
$8.2M
Project 3: MUC16-Mediated Metabolic Reprograming Induces PC MetastasisP01CA217798 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BATRA, SURINDER K. · 2018 to 2022
$8.1M
MUC16 in Pancreatic Cancer Progression and MetastasisR01CA208108 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI RADHAKRISHNAN, PRAKASH · 2017 to 2021
$1.7M
NCI NIH HHS P01 CA217798NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA208108NCI NIH HHS R35 CA232130
6 · The paper itself

Abstract

Aberrantly expressed glycans on mucins such as mucin-16 (MUC16) are implicated in the biology that promotes ovarian cancer (OC) malignancy. Here, we investigated the theranostic potential of a humanized antibody, huAR9.6, targeting fully glycosylated and hypoglycosylated MUC16 isoforms.

Indexed as

Antibodies, Monoclonal, HumanizedCA-125 AntigenMucinsOvarian NeoplasmsAnimalsApoptosisCell Line, TumorFemaleHumansMembrane ProteinsMicePentetic AcidPrecision MedicineTissue DistributionAntibodies, Monoclonal, HumanizedCA-125 AntigenMembrane ProteinsMUC16 protein, humanMucinsPentetic AcidhuAR9.6MUC16ovarian cancerPET imagingradioimmunotherapy

Identifiers

PMID38485271
PMCPMC10995531
OpenAlexW4392818830

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.