Evidence map›Paper›PMID 38485090›Full record

ArticleOphthalmology. Retina2024

Frequency and Distribution of Ophthalmic Surgical Procedures among Patients with Inherited Retinal Diseases.

Lukas Mees, Mingyi Li, Bani Antonio-Aguirre, Tin Yan Alvin Liu, Adela Wu, Xiangrong Kong, Mandeep S Singh

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology. Retina, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lukas MeesRetina Division, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland.
Mingyi LiDepartment of Epidemiology and Population Health, School of Medicine, Stanford University, Stanford, California; Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
Bani Antonio-AguirreRetina Division, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland.
Tin Yan Alvin LiuRetina Division, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland.
Adela WuRetina Division, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland; Department of Neurosurgery, Stanford Health Care, Stanford, California.
Xiangrong KongRetina Division, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland; Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
Mandeep S SinghRetina Division, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland; Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland. Electronic address: singhcorrespauth@gmail.com.
Johns Hopkins University · US

Funding

Developing photoreceptor repair for macular degeneration therapy.R01EY033103 · NEI · JOHNS HOPKINS UNIVERSITY · PI SINGH, MANDEEP · 2021 to 2025
$2.0M
NEI NIH HHS R01 EY033103
6 · The paper itself

Abstract

objectiveIn this study, we aimed to characterize the frequency and distribution of ocular surgeries in patients with inherited retinal diseases (IRDs) and evaluate associated patient and disease factors.

designRetrospective cohort.

participantsSubjects aged ≥ 18 years who were followed at the Johns Hopkins Genetic Eye Disease Center.

methodsWe studied a retrospective cohort of patients with an IRD diagnosis to analyze the occurrence of laser and incisional surgeries. Subjects were categorized into 2 groups: central dysfunction (macular/cone/cone-rod dystrophy, "MCCRD group") and panretinal or peripheral dysfunction (retinitis pigmentosa-like, "RP group"). Genetic testing status was recorded. The association of patient and disease factors on the frequency, distribution, and timing of surgeries was analyzed.

main outcome measuresPrevalence, prevalence odds ratio (POR), hazard ratio (HR) of ophthalmic procedures by phenotype.

resultsA total of 1472 eyes of 736 subjects were evaluated. Among them, 31.3% (n = 230) had undergone ocular surgery, and 78.3% of those (n = 180/230) had a history of more than 1 surgery. A total of 602 surgical procedures were analyzed. Cataract extraction with intraocular lens implantation (CEIOL) was the most common (51.2%), followed by yttrium aluminum garnet capsulotomy, refractive surgery, retinal surgery, and others. Cataract extraction with intraocular lens implantation occurred more frequently in RP than in MCCRD subjects (POR, 2.59; P = 0.002). Retinitis pigmentosa subjects underwent CEIOL at a younger age than patients with MCCRD (HR, 2.11; P < 0.001).

conclusionsApproximately one-third of patients with IRD had a history of laser or incisional surgery. Cataract extraction with intraocular lens implantation was the most common surgery; its frequency and timing may be associated with the IRD phenotype. This data may inform the design of prospective research. Such efforts may illuminate routine clinical decision-making and contribute to surgical strategy development for cell and gene therapy delivery. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Indexed as

Retinal DiseasesAdolescentAdultAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedOphthalmologic Surgical ProceduresPrevalenceRetrospective StudiesVisual AcuityYoung AdultCataract extractioncell therapygene therapyRetinal dystrophiesVitrectomy

Identifiers

PMID38485090
PMCPMC11377160
OpenAlexW4392696643

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.