Evidence map›Paper›PMID 38485055›Full record

ArticleTumour virus research2024

HPV16 E7 modulates the cell surface expression of MET and CD109 via the AP2 complex.

Oscar Trejo-Cerro, Om Basukala, Michael P Myers, Lawrence Banks

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tumour virus research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Oscar Trejo-CerroInternational Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34149, Trieste, Italy. Electronic address: oscar.trejo@icgeb.org.
Om BasukalaInternational Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34149, Trieste, Italy; Dana-Farber Cancer Institute, 450 Brookline Avenue, Mayer 440, Boston, MA, 02215, USA.
Michael P MyersInternational Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34149, Trieste, Italy.
Lawrence BanksInternational Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34149, Trieste, Italy.
International Centre for Genetic Engineering and Biotechnology · ITDana-Farber Cancer Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple cellular pathways are affected by HPV E6 and E7 oncoproteins, including endocytic and cellular trafficking. HPV-16 E7 can target the adaptor protein (AP) complex, which contains proteins important during endocytosis transport. To further investigate the role of HPV E7 during this process, we analysed the expression of cell surface proteins in NIKS cells expressing HPV-16 E7. We show that different cell surface proteins are regulated by HPV-16 E7 via interaction with AP2. We observed that the expression of MET and CD109 membrane protein seems to be upregulated in cells expressing E7. Moreover, the interaction of MET and CD109 with AP2 proteins is disrupted by HPV-16 E7. In addition, in the absence of HPV-16 E7, there is a downregulation of the cell membrane expression of MET and CD109 in HPV-positive cell lines. These results expand our knowledge of the functions of E7 and open new potential cellular pathways affected by this oncoprotein.

Indexed as

Antigens, CDHuman papillomavirus 16Papillomavirus E7 ProteinsProto-Oncogene Proteins c-metAdaptor Protein Complex 2Cell MembraneEndocytosisGPI-Linked ProteinsHumansNeoplasm ProteinsPapillomavirus InfectionsAdaptor Protein Complex 2Antigens, CDCD109 protein, humanGPI-Linked ProteinsMET protein, humanNeoplasm Proteinsoncogene protein E7, Human papillomavirus type 16Papillomavirus E7 ProteinsProto-Oncogene Proteins c-metAP2 complexCD109HPV E7MET

Identifiers

PMID38485055
PMCPMC10958106
OpenAlexW4392696678

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.